GKAP1 Regulates insulin-dependent IRS1 tyrosine phosphorylation in adipocytes by modulating the availability of IRS1 to IR tyrosine kinase. Its association with IRS1 is required for insulin-induced translocation of SLC2A4 to the cell membrane. Involved in TNF-induced impairment of insulin-dependent IRS1 tyrosine phosphorylation. Belongs to the GKAP1 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of mouse Ortholog: 13 B1|13 30.97 cM
Cellular Component:  Golgi apparatus
Molecular Function:  identical protein binding; protein binding
Biological Process:  G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger; positive regulation of insulin receptor signaling pathway; signal transduction
Reference #:  Q9JMB0 (UniProtKB)
Alt. Names/Synonyms: 42 kD cGMP-dependent protein kinase anchoring protein; 42kD; 42kDa; 4933400B15Rik; cGMP-dependent protein kinase anchoring protein; cGMP-dependent protein kinase-anchoring protein of 42 kDa; D13Ertd340; D13Ertd340e; G kinase anchoring protein 1; G kinase-anchoring protein 1; Gkap; Gkap1; Gkap42
Gene Symbols: Gkap1
Molecular weight: 41,763 Da
Basal Isoelectric point: 8.89  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene