SMAD5 Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor-regulated SMAD (R-SMAD). Belongs to the dwarfin/SMAD family. Ubiquitous. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 5q31.1
Cellular Component:  cytoplasm; cytosol; nucleoplasm; nucleus; protein-containing complex; SMAD protein complex; transcription factor complex
Molecular Function:  DEAD/H-box RNA helicase binding; DNA-binding transcription factor activity, RNA polymerase II-specific; metal ion binding; protein binding; RNA polymerase II proximal promoter sequence-specific DNA binding; transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity; ubiquitin protein ligase binding
Biological Process:  BMP signaling pathway; bone development; cardiac muscle contraction; cartilage development; cellular response to organic cyclic compound; embryonic pattern specification; erythrocyte differentiation; germ cell development; Mullerian duct regression; negative regulation of transcription by RNA polymerase II; osteoblast fate commitment; positive regulation of osteoblast differentiation; positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus; positive regulation of transcription, DNA-templated; protein phosphorylation; signal transduction; SMAD protein signal transduction; transforming growth factor beta receptor signaling pathway; ureteric bud development
Reference #:  Q99717 (UniProtKB)
Alt. Names/Synonyms: DKFZp781C1895; DKFZp781O1323; Dwfc; hSmad5; JV5-1; MAD homolog 5; MAD, mothers against decapentaplegic homolog 5; MADH5; Mothers against decapentaplegic homolog 5; mothers against decapentaplegic, drosophila, homolog of, 5; Mothers against DPP homolog 5; SMA- and MAD-related protein 5; SMAD 5; SMAD family member 5; SMAD, mothers against DPP homolog 5; SMAD5
Gene Symbols: SMAD5
Molecular weight: 52,258 Da
Basal Isoelectric point: 7.63  Predict pI for various phosphorylation states
CST Pathways:  ESC Pluripotency and Differentiation  |  TGF-ß Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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SMAD5

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein