SMAD5 transcription factor phosphorylated and activated by bone morphogenetic protein receptor kinases. Phosphorylated Smads dimerize with collaborating Smad4 and are translocated into the nucleus, where they regulate transcription of target genes. Participates in a wide range of critical processes including morphogenesis, cell-fate determination, proliferation, differentiation and apoptosis. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 5q31.1
Cellular Component:  cytoplasm; cytosol; intracellular; nucleoplasm; nucleus; SMAD protein complex; transcription factor complex
Molecular Function:  DEAD/H-box RNA helicase binding; metal ion binding; protein binding; transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity; ubiquitin protein ligase binding
Biological Process:  BMP signaling pathway; cardiac muscle contraction; cartilage development; cellular response to organic cyclic compound; embryonic pattern specification; erythrocyte differentiation; germ cell development; Mullerian duct regression; negative regulation of transcription from RNA polymerase II promoter; osteoblast fate commitment; positive regulation of osteoblast differentiation; positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus; positive regulation of transcription, DNA-templated; protein amino acid phosphorylation; signal transduction; transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway; ureteric bud development
Reference #:  Q99717 (UniProtKB)
Alt. Names/Synonyms: DKFZp781C1895; DKFZp781O1323; Dwfc; hSmad5; JV5-1; MAD homolog 5; MAD, mothers against decapentaplegic homolog 5; MADH5; Mothers against decapentaplegic homolog 5; mothers against decapentaplegic, drosophila, homolog of, 5; Mothers against DPP homolog 5; SMA- and MAD-related protein 5; SMAD 5; SMAD family member 5; SMAD, mothers against DPP homolog 5; SMAD5
Gene Symbols: SMAD5
Molecular weight: 52,258 Da
Basal Isoelectric point: 7.63  Predict pI for various phosphorylation states
CST Pathways:  ESC Pluripotency and Differentiation  |  TGF-ß Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein