PLCB4 The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This form has a role in retina signal transduction. Preferentially expressed in the retina. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - inositol phosphate; EC; Phospholipase
Chromosomal Location of human Ortholog: 20p12.3-p12.2
Cellular Component:  cytosol; dendrite; glutamatergic synapse; nucleus; parallel fiber to Purkinje cell synapse; postsynaptic density; smooth endoplasmic reticulum
Molecular Function:  calcium ion binding; phospholipase C activity; protein binding
Biological Process:  G protein-coupled receptor signaling pathway; inositol phosphate metabolic process; intracellular signal transduction; lipid catabolic process; modulation of chemical synaptic transmission
Disease: Auriculocondylar Syndrome 2
Reference #:  Q15147 (UniProtKB)
Alt. Names/Synonyms: 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4; ARCND2; dJ1119D9.2 (Phopholipase C, beta 4 (1-Phosphatidylinositol-4,5-Bisphosphate Phosphodiesterase Beta 4)); FLJ16169; inositoltrisphosphohydrolase; monophosphatidylinositol phosphodiesterase; phosphoinositidase C; phosphoinositide phospholipase C; Phosphoinositide phospholipase C-beta-4; phospholipase C beta 4; phospholipase C, beta 4; Phospholipase C-beta-4; PI-PLC; PLC-beta-4; PLCB4; triphosphoinositide phosphodiesterase
Gene Symbols: PLCB4
Molecular weight: 134,464 Da
Basal Isoelectric point: 6.47  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  AMPK Signaling  |  ErbB/HER Signaling  |  GPCR Signaling to MAPKs
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein