N-PAC Putative oxidoreductase that is recruited on chromatin and promotes KDM1B demethylase activity. Recognizes and binds trimethylated 'Lys-36' of histone H3 (H3K36me3). Regulates p38 MAP kinase activity by mediating stress activation of p38alpha/MAPK14 and specifically regulating MAPK14 signaling. Indirectly promotes phosphorylation of MAPK14 and activation of ATF2. The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6. Belongs to the HIBADH-related family. NP60 subfamily. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 1.-.-.-; Oxidoreductase
Chromosomal Location of Human Ortholog: 16 A1|16 2.49 cM
Cellular Component:  cytosol; Golgi apparatus; nuclear speck; nucleoplasm; nucleosome; nucleus
Molecular Function:  DNA binding; histone binding; methylated histone binding; NAD binding; NADP binding; oxidoreductase activity
Biological Process:  oxidation-reduction process
Reference #:  Q922P9 (UniProtKB)
Alt. Names/Synonyms: 2810419J22Rik; 3930401K13Rik; AW545332; cytokine-like nuclear factor n-pac; Glyoxylate reductase 1 homolog; glyoxylate reductase 1 homolog (Arabidopsis); Glyr1; Np60; Npac; Nuclear protein NP60; Putative oxidoreductase GLYR1
Gene Symbols: Glyr1
Molecular weight: 59,716 Da
Basal Isoelectric point: 9.31  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene