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N-PAC
Putative oxidoreductase that is recruited on chromatin and promotes KDM1B demethylase activity. Recognizes and binds trimethylated 'Lys-36' of histone H3 (H3K36me3). Regulates p38 MAP kinase activity by mediating stress activation of p38alpha/MAPK14 and specifically regulating MAPK14 signaling. Indirectly promotes phosphorylation of MAPK14 and activation of ATF2. The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6. Belongs to the HIBADH-related family. NP60 subfamily. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 1.-.-.-; Oxidoreductase |
| Chromosomal Location of mouse Ortholog: 16 A1|16 2.49 cM |
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Cellular Component:
chromatin; chromosome; cytosol; nucleoplasm; nucleosome; nucleus
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Molecular Function:
chromatin binding; chromatin-protein adaptor activity; DNA binding; histone binding; methylated histone binding; NAD binding; NADP binding; nucleosome binding; oxidoreductase activity; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
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Biological Process:
positive regulation of histone acetylation; positive regulation of transcription by RNA polymerase II; transcription initiation-coupled chromatin remodeling
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Reference #:
Q922P9
(UniProtKB)
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Alt. Names/Synonyms: 2810419J22Rik; 3930401K13Rik; AW545332; Cytokine-like nuclear factor N-PAC; Glyoxylate reductase 1 homolog; glyoxylate reductase 1 homolog (Arabidopsis); Glyr1; N-PAC; NDF; Np60; Npac; Nuclear protein NP60; Putative oxidoreductase GLYR1
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Gene Symbols: Glyr1
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Molecular weight:
59,716 Da
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Basal Isoelectric point:
9.31
Predict pI for various phosphorylation states
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