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INT4
Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex. Belongs to the Integrator subunit 4 family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Transcription initiation complex |
| Chromosomal Location of human Ortholog: 11q14.1 |
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Cellular Component:
integrator complex; nucleolus; nucleoplasm; nucleus
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Molecular Function:
protein binding
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Biological Process:
regulation of transcription elongation by RNA polymerase II; snRNA processing
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Reference #:
Q96HW7
(UniProtKB)
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Alt. Names/Synonyms: Int4; Integrator complex subunit 4; INTS4; MGC16733; MST093; MSTP093
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Gene Symbols: INTS4
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Molecular weight:
108,171 Da
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Basal Isoelectric point:
6
Predict pI for various phosphorylation states
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