SMAD3 transcription factor phosphorylated and activated by TGF-beta-type receptors. A receptor-regulated Smad (R-smad). Binds directly to consensus DNA-binding elements in the promoters of target genes. In mouse required for establishemnt of the mucosal immune response and proper development of skeleton. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nuclear receptor co-regulator; Transcription factor
Chromosomal Location of Human Ortholog: 15q22.33
Cellular Component:  cytoplasm; cytosol; heteromeric SMAD protein complex; nuclear chromatin; nuclear inner membrane; nucleoplasm; nucleus; plasma membrane; receptor complex; SMAD protein complex; transcription factor complex
Molecular Function:  beta-catenin binding; bHLH transcription factor binding; chromatin DNA binding; co-SMAD binding; collagen binding; DEAD/H-box RNA helicase binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; enhancer binding; glucocorticoid receptor binding; identical protein binding; mineralocorticoid receptor binding; phosphatase binding; primary miRNA binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein kinase binding; proximal promoter sequence-specific DNA binding; R-SMAD binding; RNA polymerase II activating transcription factor binding; RNA polymerase II proximal promoter sequence-specific DNA binding; sequence-specific DNA binding; transcription coregulator activity; transcription factor binding; transcription regulatory region DNA binding; transforming growth factor beta receptor binding; transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity; ubiquitin binding; ubiquitin protein ligase binding; zinc ion binding
Biological Process:  activation of cysteine-type endopeptidase activity involved in apoptotic process; activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; activin receptor signaling pathway; adrenal gland development; cell cycle arrest; cell-cell junction organization; cellular response to cytokine stimulus; cellular response to transforming growth factor beta stimulus; developmental growth; embryonic cranial skeleton morphogenesis; embryonic foregut morphogenesis; embryonic pattern specification; endoderm development; evasion or tolerance of host defenses by virus; extrinsic apoptotic signaling pathway; heart looping; immune response; immune system development; in utero embryonic development; lens fiber cell differentiation; liver development; mesoderm formation; negative regulation of apoptotic process; negative regulation of cardiac muscle hypertrophy in response to stress; negative regulation of cell growth; negative regulation of cytosolic calcium ion concentration; negative regulation of fat cell differentiation; negative regulation of inflammatory response; negative regulation of lung blood pressure; negative regulation of mitotic cell cycle; negative regulation of osteoblast differentiation; negative regulation of osteoblast proliferation; negative regulation of protein catabolic process; negative regulation of transcription by RNA polymerase II; negative regulation of transforming growth factor beta receptor signaling pathway; negative regulation of wound healing; nodal signaling pathway; osteoblast development; paraxial mesoderm morphogenesis; pericardium development; positive regulation of alkaline phosphatase activity; positive regulation of bone mineralization; positive regulation of canonical Wnt signaling pathway; positive regulation of cell migration; positive regulation of chondrocyte differentiation; positive regulation of DNA-binding transcription factor activity; positive regulation of epithelial to mesenchymal transition; positive regulation of extracellular matrix assembly; positive regulation of focal adhesion assembly; positive regulation of gene expression; positive regulation of interleukin-1 beta production; positive regulation of nitric oxide biosynthetic process; positive regulation of positive chemotaxis; positive regulation of pri-miRNA transcription by RNA polymerase II; positive regulation of protein import into nucleus; positive regulation of stress fiber assembly; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; positive regulation of transforming growth factor beta3 production; primary miRNA processing; protein deubiquitination; protein stabilization; regulation of binding; regulation of epithelial cell proliferation; regulation of immune response; regulation of striated muscle tissue development; regulation of transcription by RNA polymerase II; regulation of transforming growth factor beta receptor signaling pathway; regulation of transforming growth factor beta2 production; response to hypoxia; signal transduction involved in regulation of gene expression; SMAD protein complex assembly; SMAD protein signal transduction; somitogenesis; T cell activation; thyroid gland development; transdifferentiation; transforming growth factor beta receptor signaling pathway; ureteric bud development; wound healing
Disease: Loeys-dietz Syndrome 3
Reference #:  P84022 (UniProtKB)
Alt. Names/Synonyms: DKFZp586N0721; DKFZp686J10186; hMAD-3; hSMAD3; HSPC193; HsT17436; JV15-2; MAD homolog 3; mad homolog JV15-2; mad protein homolog; MAD, mothers against decapentaplegic homolog 3; Mad3; MADH3; MGC60396; Mothers against decapentaplegic homolog 3; Mothers against DPP homolog 3; SMA- and MAD-related protein 3; SMAD 3; SMAD family member 3; SMAD, mothers against DPP homolog 3; SMAD3
Gene Symbols: SMAD3
Molecular weight: 48,081 Da
Basal Isoelectric point: 6.73  Predict pI for various phosphorylation states
CST Pathways:  Angiogenesis  |  ESC Pluripotency and Differentiation  |  G1/S Checkpoint  |  TGF-ß Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA  |  InnateDB  |  Ensembl Protein