SULT1A3 Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic monoamines (neurotransmitters such as dopamine, norepinephrine and serotonin) and phenolic and catechol drugs. Belongs to the sulfotransferase 1 family. Liver, colon, kidney, lung, brain, spleen, small intestine, placenta and leukocyte. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Energy Metabolism - sulfur; Transferase
Chromosomal Location of Human Ortholog: 16p11.2
Cellular Component:  cytosol
Molecular Function:  amine sulfotransferase activity; aryl sulfotransferase activity; protein binding; sulfate binding; sulfotransferase activity
Biological Process:  3'-phosphoadenosine 5'-phosphosulfate metabolic process; calcineurin-mediated signaling; cellular response to dopamine; dopamine catabolic process; dopamine receptor signaling pathway; ERK1 and ERK2 cascade; ethanol catabolic process; flavonoid metabolic process; IRE1-mediated unfolded protein response; negative regulation of neuron death; NMDA selective glutamate receptor signaling pathway; steroid metabolic process; sulfation; xenobiotic metabolic process
Reference #:  P0DMM9 (UniProtKB)
Alt. Names/Synonyms: Aryl sulfotransferase 1A3/1A4; Catecholamine-sulfating phenol sulfotransferase; dopamine-specific sulfotransferase; HAST; HAST3; M-PST; MGC117469; monoamine-preferring sulfotransferase; Monoamine-sulfating phenol sulfotransferase; monoamine-sulfating phenosulfotransferase; phenol sulfotransferase 1A5; phenol sulfotransferase 1A5*4; Placental estrogen sulfotransferase; ST1A3; ST1A3/ST1A4; ST1A4; ST1A5; STM; sulfokinase; Sulfotransferase 1A3; Sulfotransferase 1A3/1A4; Sulfotransferase 1A4; sulfotransferase family 1A member 3; sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3; Sulfotransferase, monoamine-preferring; SULT1A3; SULT1A4; thermolabile (monoamine, M form) phenol sulfotransferase; Thermolabile phenol sulfotransferase; TL-PST
Gene Symbols: SULT1A3
Molecular weight: 34,196 Da
Basal Isoelectric point: 5.68  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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