SULT1A1 Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk. Belongs to the sulfotransferase 1 family. Liver, lung, adrenal, brain, platelets and skin. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Energy Metabolism - sulfur; Transferase
Chromosomal Location of human Ortholog: 16p11.2
Cellular Component:  cytosol
Molecular Function:  aryl sulfotransferase activity; flavonol 3-sulfotransferase activity; protein binding; steroid sulfotransferase activity; sulfotransferase activity
Biological Process:  3'-phosphoadenosine 5'-phosphosulfate metabolic process; amine metabolic process; catecholamine metabolic process; estrogen metabolic process; ethanol catabolic process; flavonoid metabolic process; sulfation; xenobiotic metabolic process
Reference #:  P50225 (UniProtKB)
Alt. Names/Synonyms: Aryl sulfotransferase 1; HAST1/HAST2; MGC131921; MGC5163; P-PST; P-PST 1; Phenol sulfotransferase 1; phenol-preferring phenol sulfotransferase1; Phenol-sulfating phenol sulfotransferase 1; PST; ST1A1; ST1A3; STP; STP1; Sulfotransferase 1A1; sulfotransferase family 1A member 1; sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1; SULT1A1; Thermostable phenol sulfotransferase; thermostable phenol sulfotransferase1; Ts-PST; TSPST1
Gene Symbols: SULT1A1
Molecular weight: 34,165 Da
Basal Isoelectric point: 6.16  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein