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SULT1A1
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk. Belongs to the sulfotransferase 1 family. Liver, lung, adrenal, brain, platelets and skin. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.8.2.1; Energy Metabolism - sulfur; Transferase |
| Chromosomal Location of human Ortholog: 16p11.2 |
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Cellular Component:
cytoplasm; cytosol
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Molecular Function:
3'-phosphoadenosine 5'-phosphosulfate binding; aryl sulfotransferase activity; flavonol 3-sulfotransferase activity; protein binding; steroid sulfotransferase activity; sulfotransferase activity
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Biological Process:
3'-phosphoadenosine 5'-phosphosulfate metabolic process; amine metabolic process; catecholamine metabolic process; estrogen metabolic process; ethanol catabolic process; flavonoid metabolic process; sulfation; xenobiotic metabolic process
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Reference #:
P50225
(UniProtKB)
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Alt. Names/Synonyms: Aryl sulfotransferase 1; HAST1/HAST2; MGC131921; MGC5163; P-PST; P-PST 1; Phenol sulfotransferase 1; phenol-preferring phenol sulfotransferase1; Phenol-sulfating phenol sulfotransferase 1; PST; ST1A1; ST1A3; STP; STP1; Sulfotransferase 1A1; sulfotransferase family 1A member 1; sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1; SULT1A1; Thermostable phenol sulfotransferase; thermostable phenol sulfotransferase1; Ts-PST; TSPST1
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Gene Symbols: SULT1A1
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Molecular weight:
34,165 Da
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Basal Isoelectric point:
6.16
Predict pI for various phosphorylation states
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