PYHIN1 iso2 Major mediator of the tumor suppressor activity of IFN in breast cancer cells. Promotes ubiquitination and subsequent degradation of MDM2, which leads to p53/TP53 stabilization. Promotes ubiquitination and subsequent degradation of HDAC1, which in turn enhances maspin expression, and impairs invasive activity of cancer cells. Belongs to the HIN-200 family. Expressed in spleen, lymph node and peripheral blood leukocytes, and at lower levels in thymus, bone marrow and fetal liver. Down-regulated in breast tumors. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Tumor suppressor
Chromosomal Location of Human Ortholog: 1q23.1
Cellular Component:  nuclear speck; protein-containing complex
Molecular Function:  ubiquitin protein ligase binding
Biological Process:  activation of innate immune response; cell cycle; cellular response to interferon-alpha; cellular response to interferon-beta; positive regulation of DNA binding; positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; positive regulation of protein localization to nucleus; positive regulation of transcription, DNA-templated; positive regulation of ubiquitin-dependent protein catabolic process; protein destabilization; protein stabilization
Reference #:  Q6K0P9-2 (UniProtKB)
Alt. Names/Synonyms: IFIX; Interferon-inducible protein X; MGC23885; PYHIN1; pyrin and HIN domain family, member 1; Pyrin and HIN domain-containing protein 1; RP11-520H16.1
Gene Symbols: PYHIN1
Molecular weight: 54,113 Da
Basal Isoelectric point: 9.83  Predict pI for various phosphorylation states
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PYHIN1 iso2

Protein Structure Not Found.

Cross-references to other databases:  cBioPortal  |  Wikipedia  |  Pfam  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene