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PYHIN1 iso2
Major mediator of the tumor suppressor activity of IFN in breast cancer cells. Promotes ubiquitination and subsequent degradation of MDM2, which leads to p53/TP53 stabilization. Promotes ubiquitination and subsequent degradation of HDAC1, which in turn enhances maspin expression, and impairs invasive activity of cancer cells. Belongs to the HIN-200 family. Expressed in spleen, lymph node and peripheral blood leukocytes, and at lower levels in thymus, bone marrow and fetal liver. Down-regulated in breast tumors. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Tumor suppressor |
| Chromosomal Location of human Ortholog: 1q23.1 |
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Cellular Component:
cytosol; nuclear speck; nucleolus; nucleoplasm; protein-containing complex
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Molecular Function:
double-stranded DNA binding; ubiquitin protein ligase binding
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Biological Process:
activation of innate immune response; cell cycle; cellular response to interferon-alpha; cellular response to interferon-beta; positive regulation of DNA binding; positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; positive regulation of DNA-templated transcription; positive regulation of protein localization to nucleus; positive regulation of ubiquitin-dependent protein catabolic process; protein destabilization; protein stabilization
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Reference #:
Q6K0P9-2
(UniProtKB)
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Alt. Names/Synonyms: IFIX; Interferon-inducible protein X; MGC23885; PYHIN1; PYHIN1 iso2; pyrin and HIN domain family member 1; pyrin and HIN domain family, member 1; Pyrin and HIN domain-containing protein 1; RP11-520H16.1
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Gene Symbols: PYHIN1
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Molecular weight:
54,113 Da
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Basal Isoelectric point:
9.83
Predict pI for various phosphorylation states
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