SMAD1 Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Belongs to the dwarfin/SMAD family. Ubiquitous. Highest expression seen in the heart and skeletal muscle. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of human Ortholog: 4q31.21
Cellular Component:  cytoplasm; cytosol; integral component of membrane; nuclear inner membrane; nucleoplasm; nucleus; protein-containing complex; SMAD protein complex; transcription factor complex
Molecular Function:  co-SMAD binding; DEAD/H-box RNA helicase binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; I-SMAD binding; identical protein binding; metal ion binding; primary miRNA binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein kinase binding; RNA polymerase II proximal promoter sequence-specific DNA binding; transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
Biological Process:  BMP signaling pathway; bone development; cardiac muscle cell proliferation; cartilage development; cellular response to organic cyclic compound; embryonic pattern specification; gamete generation; hindbrain development; homeostatic process; inflammatory response; MAPK cascade; mesodermal cell fate commitment; midbrain development; negative regulation of cell proliferation; osteoblast fate commitment; positive regulation of cartilage development; positive regulation of gene expression; positive regulation of osteoblast differentiation; positive regulation of pri-miRNA transcription by RNA polymerase II; positive regulation of sprouting angiogenesis; positive regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus; primary miRNA processing; protein deubiquitination; signal transduction; SMAD protein complex assembly; SMAD protein signal transduction; transforming growth factor beta receptor signaling pathway; ureteric bud development
Reference #:  Q15797 (UniProtKB)
Alt. Names/Synonyms: BSP-1; BSP1; hSMAD1; JV4-1; JV41; MAD homolog 1; MAD, mothers against decapentaplegic homolog 1; Mad-related protein 1; MADH1; MADR1; Mothers against decapentaplegic homolog 1; Mothers against DPP homolog 1; SMAD 1; SMAD family member 1; SMAD, mothers against DPP homolog 1; SMAD1; TGF-beta signaling protein 1; transforming growth factor-beta signaling protein 1; Transforming growth factor-beta-signaling protein 1
Gene Symbols: SMAD1
Molecular weight: 52,260 Da
Basal Isoelectric point: 6.9  Predict pI for various phosphorylation states
CST Pathways:  ESC Pluripotency and Differentiation  |  TGF-ß Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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