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NALP4
May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors. Acts as a negative regulator of the type I interferon signaling pathway by serving as an adapter to promote DTX4-mediated ubiquitination of activated TBK1, and its subsequent degradation. Suppresses NF-kappaB induction by the cytokines TNFA and IL1B, suggesting that it operates at a point of convergence in these two cytokine signaling pathways. Belongs to the NLRP family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cancer Testis Antigen (CTA) |
| Chromosomal Location of Human Ortholog: 19q13.43 |
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Cellular Component:
cytosol
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Molecular Function:
ATP binding
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Biological Process:
inflammatory response; regulation of type I interferon production
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Reference #:
Q96MN2
(UniProtKB)
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Alt. Names/Synonyms: Cancer/testis antigen 58; CLR19.5; CT58; FLJ32126; NACHT, leucine rich repeat and PYD containing 4; NACHT, LRR and PYD containing protein 4; NACHT, LRR and PYD domains-containing protein 4; NALP4; NLR family pyrin domain containing 4; NLR family, pyrin domain containing 4; NLRP4; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 4; PAAD and NACHT-containing protein 2; PAN2; PYPAF4; PYRIN and NACHT-containing protein 2; PYRIN-containing APAF1-like protein 4; Ribonuclease inhibitor 2; RNH2
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Gene Symbols: NLRP4
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Molecular weight:
113,415 Da
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Basal Isoelectric point:
5.54
Predict pI for various phosphorylation states
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