IFT140 Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs). Plays a pivotal role in proper development and function of ciliated cells through its role in ciliogenesis and/or cilium maintenance. Required for the development and maintenance of the outer segments of rod and cone photoreceptor cells. Plays a role in maintenance and the delivery of opsin to the outer segment of photoreceptor cells. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of human Ortholog: 16p13.3
Cellular Component:  axoneme; centriole; centrosome; ciliary basal body; ciliary tip; cilium; cone photoreceptor outer segment; intraciliary transport particle A; photoreceptor connecting cilium
Molecular Function:  protein binding
Biological Process:  cilium assembly; determination of left/right symmetry; embryonic brain development; embryonic camera-type eye development; embryonic cranial skeleton morphogenesis; embryonic digit morphogenesis; heart development; intraciliary retrograde transport; neural tube patterning; non-motile cilium assembly; photoreceptor cell outer segment organization; protein localization to cilium; regulation of cilium assembly; regulation of smoothened signaling pathway
Disease: Retinitis Pigmentosa 80; Short-rib Thoracic Dysplasia 9 With Or Without Polydactyly
Reference #:  Q96RY7 (UniProtKB)
Alt. Names/Synonyms: c305C8.4; c380F5.1; DKFZp564L232; FLJ10306; FLJ30571; gs114; IF140; IFT140; intraflagellar transport 140; intraflagellar transport 140 homolog; intraflagellar transport 140 homolog (Chlamydomonas); Intraflagellar transport protein 140 homolog; KIAA0590; MZSDS; RP80; SRTD9; WD and tetratricopeptide repeats 2; WD and tetratricopeptide repeats protein 2; WDTC2
Gene Symbols: IFT140
Molecular weight: 165,193 Da
Basal Isoelectric point: 5.69  Predict pI for various phosphorylation states
Select Structure to View Below

IFT140

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein