NKCC1 a multi-pass membrane cation transporter protein. Aids transcellular movement of chloride across both secretory and absorptive epithelia. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume. Expressed in many tissues. Bumetanide is a potent NKCC1 antagonist. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Chromosomal Location of Human Ortholog: 18q12.1
Cellular Component:  apical plasma membrane; basolateral plasma membrane; integral component of membrane; plasma membrane
Molecular Function:  ammonium transmembrane transporter activity; cation:chloride symporter activity; potassium:chloride symporter activity; protein kinase binding; sodium ion transmembrane transporter activity; sodium:chloride symporter activity; sodium:potassium:chloride symporter activity
Biological Process:  aging; ammonium transmembrane transport; ammonium transport; cell volume homeostasis; chloride ion homeostasis; chloride transport; detection of mechanical stimulus involved in sensory perception of sound; gamma-aminobutyric acid signaling pathway; hyperosmotic response; multicellular organism growth; positive regulation of cell volume; potassium ion homeostasis; potassium ion import; potassium ion transmembrane transport; potassium ion transport; sodium ion homeostasis; sodium ion transport; transepithelial chloride transport
Reference #:  Q9QX10 (UniProtKB)
Alt. Names/Synonyms: Bsc2; Na-K-Cl cotransporter; Nkcc1; Slc12a2; solute carrier family 12 (sodium/potassium/chloride transporters), member 2; solute carrier family 12, member 2
Gene Symbols: Slc12a2
Molecular weight: 130,352 Da
Basal Isoelectric point: 6.08  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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NKCC1

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene