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NKCC1
Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume. Belongs to the SLC12A transporter family. Expressed in many tissues. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family |
| Chromosomal Location of rat Ortholog: 18q12.1 |
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Cellular Component:
apical plasma membrane; basal plasma membrane; basolateral plasma membrane; cell body; cell periphery; cell projection; cytoplasmic vesicle membrane; lateral plasma membrane; neuron projection; neuronal cell body; plasma membrane
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Molecular Function:
ammonium transmembrane transporter activity; chloride:monoatomic cation symporter activity; Hsp90 protein binding; metal ion transmembrane transporter activity; potassium ion transmembrane transporter activity; protein kinase binding; protein-folding chaperone binding; sodium:potassium:chloride symporter activity
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Biological Process:
ammonium transmembrane transport; branching involved in mammary gland duct morphogenesis; cell volume homeostasis; cellular response to chemokine; cellular response to lipopolysaccharide; cellular response to potassium ion; chloride ion homeostasis; chloride transmembrane transport; chloride transport; detection of mechanical stimulus involved in sensory perception of sound; gamma-aminobutyric acid signaling pathway; hyperosmotic response; inorganic anion import across plasma membrane; inorganic cation import across plasma membrane; intracellular chloride ion homeostasis; intracellular potassium ion homeostasis; intracellular sodium ion homeostasis; maintenance of blood-brain barrier; mammary duct terminal end bud growth; multicellular organism growth; negative regulation of vascular wound healing; positive regulation of aspartate secretion; positive regulation of cell volume; potassium ion homeostasis; potassium ion import across plasma membrane; potassium ion transport; regulation of matrix metallopeptidase secretion; regulation of spontaneous synaptic transmission; sodium ion homeostasis; sodium ion import across plasma membrane; sodium ion transmembrane transport; sodium ion transport; T cell chemotaxis; transepithelial ammonium transport; transepithelial chloride transport
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Reference #:
Q9QX10
(UniProtKB)
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Alt. Names/Synonyms: Bsc2; Na-K-Cl cotransporter; Nkcc1; Slc12a2; solute carrier family 12 (sodium/potassium/chloride transporters), member 2; solute carrier family 12, member 2
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Gene Symbols: Slc12a2
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Molecular weight:
130,352 Da
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Basal Isoelectric point:
6.08
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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