RFC1 The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Could play a role in DNA transcription regulation as well as DNA replication and/or repair. Can bind single- or double-stranded DNA. Interacts with C-terminus of PCNA. 5' phosphate residue is required for binding of the N-terminal DNA-binding domain to duplex DNA, suggesting a role in recognition of non-primer template DNA structures during replication and/or repair. Belongs to the activator 1 large subunit family. Wide tissue distribution. Undetectable in placental tissue. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA replication
Chromosomal Location of Human Ortholog: 5 C3.1|5 33.61 cM
Cellular Component:  cytoplasm; DNA replication factor C complex; Elg1 RFC-like complex; nucleolus; nucleoplasm; nucleus; protein-containing complex
Molecular Function:  ATP binding; DNA binding; DNA clamp loader activity; DNA clamp unloader activity; double-stranded DNA binding; nucleotide binding; protein domain specific binding; sequence-specific DNA binding
Biological Process:  DNA clamp unloading; DNA repair; DNA replication; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; positive regulation of transcription, DNA-templated
Reference #:  P35601 (UniProtKB)
Alt. Names/Synonyms: 140kD; 140kDa; A1 140 kDa subunit; A1-P145; Activator 1 140 kDa subunit; Activator 1 large subunit; Activator 1 subunit 1; Alp; Alp145; Differentiation-specific element-binding protein; Ibf-1; ISRE-binding protein; MGC96526; Recc; Recc1; replication factor C (activator 1) 1; replication factor C 1; Replication factor C 140 kDa subunit; Replication factor C large subunit; Replication factor C subunit 1; replication factor C, 140 kDa; RF-C 140 kDa subunit; Rfc1; RFC14; RFC140
Gene Symbols: Rfc1
Molecular weight: 125,985 Da
Basal Isoelectric point: 9.38  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene