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LLGL1
Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane. Belongs to the WD repeat L(2)GL family. Expressed in brain, kidney, and muscle but is barely seen in heart and placenta. Down-regulated or lost in all cell lines and in most of the tumor samples analyzed. Loss was associated with advanced stage of the disease. Note: This description may include information from UniProtKB.
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| Protein type: Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis |
| Chromosomal Location of human Ortholog: 17p11.2 |
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Cellular Component:
adherens junction; axon; cortical actin cytoskeleton; cytoplasm; cytoskeleton; early endosome membrane; Golgi cis cisterna; Golgi membrane; plasma membrane; trans-Golgi network membrane
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Molecular Function:
GTPase activator activity; myosin II binding; protein binding; protein kinase binding; structural molecule activity
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Biological Process:
axonogenesis; cortical actin cytoskeleton organization; establishment of spindle orientation; establishment or maintenance of epithelial cell apical/basal polarity; exocytosis; Golgi to plasma membrane transport; protein-containing complex assembly; regulation of establishment or maintenance of cell polarity; regulation of Notch signaling pathway; regulation of protein secretion
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Reference #:
Q15334
(UniProtKB)
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Alt. Names/Synonyms: DLG4; HUGL; Hugl-1; HUGL1; Human homolog to the D-lgl gene protein; L2GL1; lethal giant larvae homolog 1 (Drosophila); lethal giant larvae homolog 1, scribble cell polarity complex component; Lethal(2) giant larvae protein homolog 1; Lgl1; LLGL; LLGL scribble cell polarity complex component 1; LLGL1; LLGL1, scribble cell polarity complex component; Mgl1
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Gene Symbols: LLGL1
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Molecular weight:
115,418 Da
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Basal Isoelectric point:
5.87
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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