RICTOR Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development. Belongs to the RICTOR family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Cell cycle regulation; Ubiquitin conjugating system
Chromosomal Location of mouse Ortholog: 15|15 A1
Cellular Component:  TORC2 complex
Molecular Function:  molecular adaptor activity; protein binding; protein kinase binding; protein serine/threonine kinase activator activity; ribosome binding
Biological Process:  actin cytoskeleton organization; cellular response to nutrient levels; cytoskeleton organization; embryo development ending in birth or egg hatching; multicellular organism development; negative regulation of apoptotic process; peptidyl-serine phosphorylation; phosphorylation; positive regulation of actin filament polymerization; positive regulation of cell growth; positive regulation of endothelial cell proliferation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein kinase B signaling; positive regulation of TOR signaling; regulation of actin cytoskeleton organization; regulation of establishment of cell polarity; regulation of gene expression; regulation of GTPase activity; regulation of inflammatory response; regulation of peptidyl-serine phosphorylation; regulation of phosphorylation; regulation of protein kinase B signaling; regulation of protein phosphorylation; TOR signaling; TORC2 signaling
Reference #:  Q6QI06 (UniProtKB)
Alt. Names/Synonyms: 4921505C17Rik; 6030405M08Rik; AVO3; AVO3 homolog; AW492497; D530039E11Rik; Kiaa1999; mAVO3; Protein pianissimo; Rapamycin-insensitive companion of mTOR; Rictor; RICTR; RPTOR independent companion of MTOR, complex 2
Gene Symbols: Rictor
Molecular weight: 191,570 Da
Basal Isoelectric point: 6.8  Predict pI for various phosphorylation states
CST Pathways:  Insulin Receptor Signaling  |  mTOR Signaling  |  PI3K/Akt Signaling  |  Translation: eIF4E and p70S6K
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein