PIK3C2B Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns. Does not phosphorylate PtdIns(4,5)P2. May be involved in EGF and PDGF signaling cascades. Belongs to the PI3/PI4-kinase family. Expressed in columnar and transitional epithelia, mononuclear cells, and ganglion cells (at protein level). Widely expressed, with highest levels in thymus and placenta and lowest in peripheral blood, skeletal muscle and kidney. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.154; Kinase, lipid; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 1|1 E4
Cellular Component:  cytoplasm; cytosol; endocytic vesicle; membrane; nucleoplasm; phosphatidylinositol 3-kinase complex; plasma membrane
Molecular Function:  1-phosphatidylinositol-3-kinase activity; 1-phosphatidylinositol-4-phosphate 3-kinase activity; lipid kinase activity; protein binding
Biological Process:  autophagosome organization; cell migration; cellular response to starvation; macroautophagy; phosphatidylinositol 3-kinase signaling; phosphatidylinositol phosphorylation; phosphatidylinositol-3-phosphate biosynthetic process; phosphatidylinositol-mediated signaling; protein kinase B signaling
Reference #:  E9QAN8 (UniProtKB)
Alt. Names/Synonyms: C330011J12Rik; Gm199; P3C2B; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta; Phosphatidylinositol-4-phosphate 3-kinase; Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta; phosphoinositide-3-kinase, class 2, beta polypeptide; PI3K-C2b; PI3K-C2beta; PI3KC2beta; Pik3c2b
Gene Symbols: Pik3c2b
Molecular weight: 184,178 Da
Basal Isoelectric point: 6.63  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Adherens Junction Dynamics  |  AMPK Signaling  |  Angiogenesis  |  Apoptosis Regulation  |  ErbB/HER Signaling  |  ESC Pluripotency and Differentiation  |  Growth And Differentiation Control by MAPKs  |  IL6 Signaling  |  Inhibition of Apoptosis  |  Microtubule Dynamics  |  Mitochondrial Control of Apoptosis  |  mTOR Signaling  |  NF-kB Signaling  |  PI3K/Akt Signaling  |  Protein Kinase C Signaling  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling  |  TGF-ß Signaling  |  Translation: eIF4E and p70S6K  |  Warburg Effect
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PIK3C2B

Protein Structure Not Found.

Cross-references to other databases:  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein