MDGA1 Required for radial migration of cortical neurons in the superficial layer of the neocortex. Plays a role in the formation or maintenance of inhibitory synapses. May function by inhibiting the activity of NLGN2. Has been found in brain, heart, skeletal muscle and kidney. Found to be overexpressed in tumor tissues. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, GPI anchor
Chromosomal Location of mouse Ortholog: 17|17 A3.3
Cellular Component:  anchored component of membrane; anchored component of plasma membrane; GABA-ergic synapse; membrane; membrane raft; plasma membrane
Biological Process:  cell differentiation; cerebral cortex radially oriented cell migration; multicellular organism development; negative regulation of synapse assembly; nervous system development; neuron migration; regulation of presynapse assembly; regulation of synaptic membrane adhesion
Reference #:  Q0PMG2 (UniProtKB)
Alt. Names/Synonyms: 1200011I03Rik; GPIM; MAM domain containing glycosylphosphatidylinositol anchor 1; MAM domain-containing glycosylphosphatidylinositol anchor protein 1; Mamdc; Mamdc3; Mdga1
Gene Symbols: Mdga1
Molecular weight: 106,047 Da
Basal Isoelectric point: 8.61  Predict pI for various phosphorylation states
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MDGA1

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  Ensembl Protein