palladin Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci. Belongs to the myotilin/palladin family. Detected in both muscle and non-muscle tissues. High expression in prostate, ovary, colon, and kidney. Not detected in spleen, skeletal muscle, lung and peripheral blood lymphocytes (at protein level). Protein is overexpressed in FA6, HPAF, IMIM-PC2, SUIT-2 and PancTu-II sporadic pancreatic cancer cell lines. 9 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 8|8 B3.1
Cellular Component:  actin cytoskeleton; actin filament; axon; axonal growth cone; cell junction; cell projection; cytoplasm; cytoskeleton; cytosol; filopodium; neuronal cell body; nucleus; plasma membrane; podosome; ruffle; stress fiber
Molecular Function:  actin binding; axon guidance receptor activity; cytoskeletal protein binding
Biological Process:  actin cytoskeleton organization; cell migration; epithelial cell morphogenesis; homophilic cell adhesion via plasma membrane adhesion molecules; keratinocyte development; neuron projection development; positive regulation of podosome assembly; ruffle organization; synapse organization
Reference #:  Q9ET54 (UniProtKB)
Alt. Names/Synonyms: 2410003B16Rik; 6030492A02; 90kDa actin-associated protein palladin; Kiaa0992; MGC150248; Palladin; palladin, cytoskeletal associated protein; Palld
Gene Symbols: Palld
Molecular weight: 152,131 Da
Basal Isoelectric point: 5.87  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein