ZDHHC20 Catalyzes palmitoylation of Cys residues on target proteins. Catalyzes palmitoylation of Cys residues in the cytoplasmic C-terminus of EGFR, and modulates the duration of EGFR signaling by modulating palmitoylation-dependent EGFR internalization and degradation. Has a preference for acyl-CoA with C16 fatty acid chains. Can also utilize acyl-CoA with C14 and C18 fatty acid chains. Belongs to the DHHC palmitoyltransferase family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.3.1.225; Membrane protein, integral; Membrane protein, multi-pass; Transferase
Chromosomal Location of mouse Ortholog: 14|14 C3
Cellular Component:  cytoplasm; endoplasmic reticulum; Golgi apparatus; integral component of Golgi membrane; integral component of membrane; membrane; plasma membrane
Molecular Function:  metal ion binding; palmitoyltransferase activity; protein-cysteine S-palmitoyltransferase activity; transferase activity; transferase activity, transferring acyl groups; zinc ion binding
Biological Process:  peptidyl-L-cysteine S-palmitoylation; protein palmitoylation; protein targeting to membrane
Reference #:  Q5Y5T1 (UniProtKB)
Alt. Names/Synonyms: 4930542A17Rik; 5033406L14Rik; AI448102; B230110O18Rik; DHHC-20; DHHC-containing protein 20; HK11; Palmitoyltransferase ZDHHC20; Probable palmitoyltransferase ZDHHC20; ZDH20; Zdhhc20; Zinc finger DHHC domain-containing protein 20; zinc finger, DHHC domain containing 20
Gene Symbols: Zdhhc20
Molecular weight: 43,976 Da
Basal Isoelectric point: 8.6  Predict pI for various phosphorylation states
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ZDHHC20

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene