CASP12 Has no protease activity. May reduce cytokine release in response to bacterial lipopolysaccharide during infections. Reduces activation of NF-kappa-B in response to TNF. Belongs to the peptidase C14A family. Detected in heart, kidney, liver, lung, pancreas, small intestine, spleen, stomach, thymus and testis. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.22.-; Protease
Chromosomal Location of mouse Ortholog: 9 A1|9 2.46 cM
Cellular Component:  cytoplasm; endoplasmic reticulum
Molecular Function:  cysteine-type endopeptidase activity; cysteine-type endopeptidase activity involved in apoptotic process; cysteine-type endopeptidase activity involved in execution phase of apoptosis; cysteine-type peptidase activity; endopeptidase activity; hydrolase activity; peptidase activity; protease binding; protein binding
Biological Process:  apoptotic process; endoplasmic reticulum unfolded protein response; fibroblast apoptotic process; intrinsic apoptotic signaling pathway; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; positive regulation of apoptotic process; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of striated muscle cell apoptotic process; protein autoprocessing; protein catabolic process; proteolysis; regulation of apoptotic process; self proteolysis
Reference #:  O08736 (UniProtKB)
Alt. Names/Synonyms: CASP-12; Casp12; caspase 12; Caspase-12; caspase12; CASPC
Gene Symbols: Casp12
Molecular weight: 47,854 Da
Basal Isoelectric point: 5.95  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  ErbB/HER Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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CASP12

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein