CASP12
Has no protease activity. May reduce cytokine release in response to bacterial lipopolysaccharide during infections. Reduces activation of NF-kappa-B in response to TNF. Belongs to the peptidase C14A family. Detected in heart, kidney, liver, lung, pancreas, small intestine, spleen, stomach, thymus and testis. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: EC 3.4.22.-; Protease |
Chromosomal Location of mouse Ortholog: 9 A1|9 2.46 cM |
Cellular Component:
cytoplasm; endoplasmic reticulum
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Molecular Function:
cysteine-type endopeptidase activity; cysteine-type endopeptidase activity involved in apoptotic process; cysteine-type endopeptidase activity involved in execution phase of apoptosis; cysteine-type peptidase activity; endopeptidase activity; hydrolase activity; peptidase activity; protease binding; protein binding
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Biological Process:
apoptotic process; endoplasmic reticulum unfolded protein response; fibroblast apoptotic process; intrinsic apoptotic signaling pathway; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; positive regulation of apoptotic process; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of striated muscle cell apoptotic process; protein autoprocessing; protein catabolic process; proteolysis; regulation of apoptotic process; self proteolysis
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Reference #:
O08736
(UniProtKB)
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Alt. Names/Synonyms: CASP-12; Casp12; caspase 12; Caspase-12; caspase12; CASPC
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Gene Symbols: Casp12
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Molecular weight:
47,854 Da
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Basal Isoelectric point:
5.95
Predict pI for various phosphorylation states
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CST Pathways:
Apoptosis Regulation
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ErbB/HER Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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