S6 May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA. Belongs to the eukaryotic ribosomal protein eS6 family. Note: This description may include information from UniProtKB.

Protein type: Translation

Chromosomal Location of human Ortholog: 9p22.1

Cellular Component: cell body; cytoplasm; cytoplasmic ribonucleoprotein granule; cytosol; cytosolic ribosome; cytosolic small ribosomal subunit; dendrite; endoplasmic reticulum; nucleolus; nucleoplasm; nucleus; perinuclear region of cytoplasm; polysome; ribonucleoprotein complex; small ribosomal subunit; small-subunit processome

Molecular Function: protein binding; protein kinase binding; structural constituent of ribosome

Biological Process: activation-induced cell death of T cells; cytoplasmic translation; erythrocyte development; G1/S transition of mitotic cell cycle; gastrulation; glucose homeostasis; mammalian oogenesis stage; negative regulation of apoptotic process; placenta development; positive regulation of apoptotic process; positive regulation of cell population proliferation; ribosomal small subunit biogenesis; rRNA processing; T cell differentiation in thymus; T cell proliferation involved in immune response; TOR signaling; translation

Reference #: P62753 (UniProtKB)

Alt. Names/Synonyms: 40S ribosomal protein S6; Phosphoprotein NP33; ribosomal protein S6; RPS6; RS6; S6; S6 ribosomal protein; Small ribosomal subunit protein eS6

Gene Symbols: RPS6

Molecular weight: 28,681 Da

Basal Isoelectric point: 10.85 Predict pI for various phosphorylation states

CST Pathways: Growth And Differentiation Control by MAPKs | PI3K/Akt Signaling | Translation: eIF4E and p70S6K

Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology^®

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S6

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