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DTX2
Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. Belongs to the Deltex family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 6.3.2.-; Ligase; Transcription, coactivator/corepressor; Ubiquitin conjugating system; Ubiquitin ligase |
| Chromosomal Location of human Ortholog: 7q11.23 |
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Cellular Component:
cytoplasm; nuclear membrane; nucleoplasm
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Molecular Function:
protein binding; ubiquitin protein ligase activity; zinc ion binding
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Biological Process:
Notch signaling pathway; protein ubiquitination
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Reference #:
Q86UW9
(UniProtKB)
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Alt. Names/Synonyms: deltex 2, E3 ubiquitin ligase; deltex E3 ubiquitin ligase 2; deltex homolog 2; deltex homolog 2 (Drosophila); Deltex2; DTX2; hDTX2; KIAA1528; MGC71098; Probable E3 ubiquitin-protein ligase DTX2; Protein deltex-2; RING finger protein 58; RING-type E3 ubiquitin transferase DTX2; RNF58; zinc ion binding protein
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Gene Symbols: DTX2
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Molecular weight:
67,246 Da
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Basal Isoelectric point:
8.79
Predict pI for various phosphorylation states
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CST Pathways:
Notch Signaling
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