DTX2 Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. Homodimer. May form a heterodimer with other members of the Deltex family. Interacts with NOTCH1. Belongs to the Deltex family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.-; Ligase; Transcription, coactivator/corepressor; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 7q11.23
Cellular Component:  cytoplasm; nuclear membrane; nucleoplasm
Molecular Function:  protein binding; transferase activity; zinc ion binding
Biological Process:  Notch signaling pathway; protein ubiquitination
Reference #:  Q86UW9 (UniProtKB)
Alt. Names/Synonyms: deltex homolog 2 (Drosophila); Deltex2; DTX2; hDTX2; KIAA1528; MGC71098; Probable E3 ubiquitin-protein ligase DTX2; Protein deltex-2; RING finger protein 58; RNF58; zinc ion binding protein
Gene Symbols: DTX2
Molecular weight: 67,246 Da
Basal Isoelectric point: 8.79  Predict pI for various phosphorylation states
CST Pathways:  Notch Signaling
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DTX2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein