DTX2 Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. Belongs to the Deltex family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.-; Ligase; Transcription, coactivator/corepressor; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 7q11.23
Cellular Component:  cytoplasm; nuclear membrane; nucleoplasm
Molecular Function:  protein binding; transferase activity; zinc ion binding
Biological Process:  Notch signaling pathway; protein ubiquitination
Reference #:  Q86UW9 (UniProtKB)
Alt. Names/Synonyms: deltex 2, E3 ubiquitin ligase; deltex E3 ubiquitin ligase 2; deltex homolog 2; deltex homolog 2 (Drosophila); Deltex2; DTX2; hDTX2; KIAA1528; MGC71098; Probable E3 ubiquitin-protein ligase DTX2; Protein deltex-2; RING finger protein 58; RING-type E3 ubiquitin transferase DTX2; RNF58; zinc ion binding protein
Gene Symbols: DTX2
Molecular weight: 67,246 Da
Basal Isoelectric point: 8.79  Predict pI for various phosphorylation states
CST Pathways:  Notch Signaling
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Protein Structure Not Found.

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