ZNRF3 E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone. Along with RSPO2 and RNF43, constitutes a master switch that governs limb specification. Belongs to the ZNRF3 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.-; EC; Membrane protein, integral; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of human Ortholog: 22q12.1
Cellular Component:  integral component of plasma membrane; plasma membrane
Molecular Function:  frizzled binding; metal ion binding; protein binding; ubiquitin protein ligase activity; ubiquitin-protein transferase activity
Biological Process:  limb development; negative regulation of canonical Wnt signaling pathway; negative regulation of non-canonical Wnt signaling pathway; protein ubiquitination; regulation of Wnt signaling pathway, planar cell polarity pathway; stem cell proliferation; ubiquitin-dependent protein catabolic process; Wnt receptor catabolic process; Wnt signaling pathway
Reference #:  Q9ULT6 (UniProtKB)
Alt. Names/Synonyms: BK747E2.3; CTA-292E10.6; E3 ubiquitin-protein ligase ZNRF3; KIAA1133; novel C3HC4 type Zinc finger (ring finger); RING finger protein 203; RING-type E3 ubiquitin transferase ZNRF3; RNF203; zinc and ring finger 3; Zinc/RING finger protein 3; ZNRF3
Gene Symbols: ZNRF3
Molecular weight: 100,574 Da
Basal Isoelectric point: 8.14  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein