PD-L2 Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production. Belongs to the immunoglobulin superfamily. BTN/MOG family. Highly expressed in heart, placenta, pancreas, lung and liver and weakly expressed in spleen, lymph nodes and thymus. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 19|19 C1
Cellular Component:  cell surface; external side of plasma membrane; integral component of membrane; membrane; plasma membrane
Molecular Function:  protein binding
Biological Process:  cell surface receptor signaling pathway; cellular response to lipopolysaccharide; immune response; negative regulation of activated T cell proliferation; negative regulation of interferon-gamma production; negative regulation of interleukin-10 production; negative regulation of T cell proliferation; positive regulation of T cell proliferation; signal transduction; T cell costimulation
Reference #:  Q9WUL5 (UniProtKB)
Alt. Names/Synonyms: B7-DC; B7dc; Btdc; Butyrophilin B7-DC; butyrophilin-like protein; Cd273; F730015O22Rik; MGC124039; MGC124040; OTTMUSP00000015822; PD-1 ligand 2; PD-L2; PD1L2; PDCD1 ligand 2; Pdcd1lg2; Pdl2; Programmed cell death 1 ligand 2; Programmed death ligand 2
Gene Symbols: Pdcd1lg2
Molecular weight: 27,820 Da
Basal Isoelectric point: 8.46  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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PD-L2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene