SPTBN4 Belongs to the spectrin family. Expressed in skeletal muscle at the sarcolemma and in the muscle capillaries (at protein level) (PubMed:28540413). Abundantly expressed in brain and pancreatic islets (PubMed:11086001). 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of mouse Ortholog: 7 A3|7 15.88 cM
Cellular Component:  adherens junction; axon; axon hillock; axon initial segment; cell body fiber; cytoplasm; intercalated disc; membrane; neuronal cell body; node of Ranvier; nuclear matrix; paranode region of axon; plasma membrane; PML body; spectrin
Molecular Function:  actin binding; ankyrin binding; phosphatase binding; protein binding; spectrin binding
Biological Process:  adult behavior; adult walking behavior; axonogenesis; cardiac conduction; cellular protein localization; central nervous system projection neuron axonogenesis; clustering of voltage-gated sodium channels; fertilization; negative regulation of heart rate; positive regulation of multicellular organism growth; protein localization to plasma membrane; regulation of peptidyl-serine phosphorylation; regulation of sodium ion transport; reproductive process; sensory perception of sound; transmission of nerve impulse
Reference #:  Q8VIE5 (UniProtKB)
Alt. Names/Synonyms: 1700022P15Rik; 5830426A08Rik; beta-spectrin 4; BetaIV-spectrin sigma1; dyn; lnd; lumbosacral neuroaxonal dystrophy; neuroaxonal dystrophy; nmf26; nmf261; nmf379; OTTMUSP00000028078; quivering; qv; ROSA62; SpbIV; spectrin beta 4; Spectrin beta chain; spectrin beta chain, non-erythrocytic 4; spectrin beta, non-erythrocytic 4; Spnb4; SPTBN4
Gene Symbols: Spnb4
Molecular weight: 288,809 Da
Basal Isoelectric point: 5.71  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene