VANGL2 Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Required for cell surface localization of FZD3 and FZD6 in the inner ear. Belongs to the Vang family. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of human Ortholog: 1q23.2
Cellular Component:  apical plasma membrane; cell-cell junction; lateral plasma membrane; plasma membrane
Molecular Function:  protein binding
Biological Process:  apical protein localization; cell migration involved in kidney development; establishment of planar polarity; heart looping; neural tube closure; non-motile cilium assembly; Wnt signaling pathway, planar cell polarity pathway
Disease: Neural Tube Defects
Reference #:  Q9ULK5 (UniProtKB)
Alt. Names/Synonyms: KIAA1215; Loop-tail protein 1 homolog; loop-tail-associated protein; LPP1; LTAP; MGC119403; MGC119404; STB1; STBM; STBM1; Strabismus 1; Van Gogh-like protein 2; vang, van gogh-like 2; vang-like 2 (van gogh, Drosophila); Vang-like protein 2; VANG2; VANGL planar cell polarity protein 2; VANGL2
Gene Symbols: VANGL2
Molecular weight: 59,714 Da
Basal Isoelectric point: 9.27  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene