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VANGL2
Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Required for cell surface localization of FZD3 and FZD6 in the inner ear. Belongs to the Vang family. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; Membrane protein, integral; Membrane protein, multi-pass |
| Chromosomal Location of human Ortholog: 1q23.2 |
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Cellular Component:
apical plasma membrane; cell-cell junction; lateral plasma membrane; plasma membrane
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Molecular Function:
protein binding
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Biological Process:
apical protein localization; cell migration involved in kidney development; establishment of planar polarity; heart looping; neural tube closure; non-motile cilium assembly; Wnt signaling pathway, planar cell polarity pathway
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Disease: Neural Tube Defects
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Reference #:
Q9ULK5
(UniProtKB)
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Alt. Names/Synonyms: KIAA1215; Loop-tail protein 1 homolog; loop-tail-associated protein; LPP1; LTAP; MGC119403; MGC119404; STB1; STBM; STBM1; Strabismus 1; Van Gogh-like protein 2; vang, van gogh-like 2; vang-like 2 (van gogh, Drosophila); Vang-like protein 2; VANG2; VANGL planar cell polarity protein 2; VANGL2
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Gene Symbols: VANGL2
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Molecular weight:
59,714 Da
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Basal Isoelectric point:
9.27
Predict pI for various phosphorylation states
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