VANGL2 Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Required for cell surface localization of FZD3 and FZD6 in the inner ear. Belongs to the Vang family. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 1q23.2
Cellular Component:  apical plasma membrane; basolateral plasma membrane; cell pole; cell-cell junction; COPII-coated ER to Golgi transport vesicle; integral component of membrane; lateral plasma membrane; plasma membrane; stress fiber
Molecular Function:  protein binding
Biological Process:  anterior/posterior pattern specification; apical protein localization; cell migration involved in kidney development; cochlea morphogenesis; convergent extension involved in axis elongation; convergent extension involved in neural plate elongation; digestive tract morphogenesis; dopaminergic neuron axon guidance; establishment of body hair planar orientation; establishment of planar polarity; establishment of planar polarity involved in neural tube closure; establishment or maintenance of epithelial cell apical/basal polarity; glomerulus development; hair follicle development; heart looping; heparan sulfate proteoglycan biosynthetic process; inner ear receptor cell stereocilium organization; kidney morphogenesis; lateral sprouting involved in lung morphogenesis; membranous septum morphogenesis; muscular septum morphogenesis; neural tube closure; non-motile cilium assembly; orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis; planar cell polarity pathway involved in axis elongation; planar cell polarity pathway involved in axon guidance; planar cell polarity pathway involved in heart morphogenesis; planar cell polarity pathway involved in neural tube closure; planar dichotomous subdivision of terminal units involved in lung branching morphogenesis; positive regulation of JUN kinase activity; post-anal tail morphogenesis; regulation of actin cytoskeleton organization; regulation of Wnt signaling pathway; Rho protein signal transduction; serotonergic neuron axon guidance; somatic stem cell division; somatic stem cell population maintenance; wound healing
Disease: Neural Tube Defects
Reference #:  Q9ULK5 (UniProtKB)
Alt. Names/Synonyms: KIAA1215; Loop-tail protein 1 homolog; loop-tail-associated protein; LPP1; LTAP; MGC119403; MGC119404; STB1; STBM; STBM1; Strabismus 1; Van Gogh-like protein 2; vang, van gogh-like 2; vang-like 2 (van gogh, Drosophila); Vang-like protein 2; VANG2; VANGL planar cell polarity protein 2; VANGL2
Gene Symbols: VANGL2
Molecular weight: 59,714 Da
Basal Isoelectric point: 9.27  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene