CMKOR1 Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. Acts as coreceptor with CXCR4 for a restricted number of HIV isolates. Belongs to the G-protein coupled receptor 1 family. Atypical chemokine receptor subfamily. Expressed in monocytes, basophils, B-cells, umbilical vein endothelial cells (HUVEC) and B-lymphoblastoid cells. Lower expression detected in CD4+ T-lymphocytes and natural killer cells. In the brain, detected in endothelial cells and capillaries, and in mature neurons of the frontal cortex and hippocampus. Expressed in tubular formation in the kidney. Highly expressed in astroglial tumor endothelial, microglial and glioma cells. Expressed at low levels in normal CD34+ progenitor cells, but at very high levels in several myeloid malignant cell lines. Expressed in breast carcinomas but not in normal breast tissue (at protein level). Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of human Ortholog: 2q37.3
Cellular Component:  cell surface; clathrin-coated pit; early endosome; endosome; integral component of membrane; intracellular membrane-bounded organelle; nucleus; perinuclear region of cytoplasm; plasma membrane; recycling endosome
Molecular Function:  C-X-C chemokine binding; C-X-C chemokine receptor activity; coreceptor activity; protein binding; scavenger receptor activity
Biological Process:  angiogenesis; cell adhesion; chemokine-mediated signaling pathway; G protein-coupled receptor signaling pathway; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage; positive regulation of ERK1 and ERK2 cascade; positive regulation of mesenchymal stem cell migration; receptor internalization; vasculogenesis; viral process
Disease: Oculomotor-abducens Synkinesis
Reference #:  P25106 (UniProtKB)
Alt. Names/Synonyms: ACKR3; Atypical chemokine receptor 3; C-X-C chemokine receptor type 7; chemokine (C-X-C motif) receptor 7; Chemokine orphan receptor 1; CMKOR1; CXC-R7; CXCR-7; CXCR7; G protein-coupled receptor; G-protein coupled receptor 159; G-protein coupled receptor RDC1 homolog; GPR159; RDC-1; RDC1
Gene Symbols: ACKR3
Molecular weight: 41,493 Da
Basal Isoelectric point: 7.52  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene