TMEM55A Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate. Negatively regulates the phagocytosis of large particles by reducing phagosomal phosphatidylinositol 4,5-bisphosphate accumulation during cup formation. Ubiquitous. Note: This description may include information from UniProtKB.
Protein type: EC; Membrane protein, integral; Membrane protein, multi-pass; Phosphatase, lipid
Chromosomal Location of human Ortholog: 8q21.3
Cellular Component:  integral component of membrane; late endosome membrane; lysosomal membrane
Molecular Function:  phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity
Biological Process:  phosphatidylinositol dephosphorylation
Reference #:  Q8N4L2 (UniProtKB)
Alt. Names/Synonyms: DKFZp762O076; phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2; PIP4P2; PP4P2; PtdIns-4,5-P(2) 4-phosphatase type II; PtdIns-4,5-P2 4-Ptase II; TM55A; TMEM55A; Transmembrane protein 55A; Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase; Type 2 PtdIns-4,5-P2 4-Ptase; Type II phosphatidylinositol 4,5-bisphosphate 4-phosphatase; type II PtdIns-4,5-P(2) 4-phosphatase
Gene Symbols: PIP4P2
Molecular weight: 28,081 Da
Basal Isoelectric point: 9.07  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene