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TMEM55A
Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate. Negatively regulates the phagocytosis of large particles by reducing phagosomal phosphatidylinositol 4,5-bisphosphate accumulation during cup formation. Ubiquitous. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.1.3.78; Membrane protein, integral; Membrane protein, multi-pass; Phosphatase, lipid |
| Chromosomal Location of mouse Ortholog: 4|4 A1-A2 |
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Cellular Component:
cytoplasmic vesicle; endosome; late endosome membrane; lysosomal membrane; lysosome; membrane; phagocytic vesicle membrane; plasma membrane
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Molecular Function:
hydrolase activity; phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity
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Biological Process:
lipid metabolic process; negative regulation of phagocytosis; phosphatidylinositol dephosphorylation
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Reference #:
Q9CZX7
(UniProtKB)
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Alt. Names/Synonyms: 2610319K07Rik; AI315591; AV001360; OTTMUSP00000004891; phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2; Pip4p2; PP4P2; PtdIns-4,5-P2 4-Ptase II; TM55A; Tmem55; Tmem55a; Transmembrane protein 55A; Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase; Type 2 PtdIns-4,5-P2 4-Ptase; Type II phosphatidylinositol 4,5-bisphosphate 4-phosphatase
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Gene Symbols: Pip4p2
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Molecular weight:
28,038 Da
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Basal Isoelectric point:
9.07
Predict pI for various phosphorylation states
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| Select Structure to View Below |
TMEM55A
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