TMEM55A Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate. Negatively regulates the phagocytosis of large particles by reducing phagosomal phosphatidylinositol 4,5-bisphosphate accumulation during cup formation. Ubiquitous. Note: This description may include information from UniProtKB.
Protein type: EC; Membrane protein, integral; Membrane protein, multi-pass; Phosphatase, lipid
Chromosomal Location of mouse Ortholog: 4|4 A1-A2
Cellular Component:  cytoplasmic vesicle; endosome; late endosome membrane; lysosomal membrane; lysosome; membrane; phagocytic vesicle membrane; plasma membrane
Molecular Function:  hydrolase activity; phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity
Biological Process:  lipid metabolic process; negative regulation of phagocytosis; phosphatidylinositol dephosphorylation
Reference #:  Q9CZX7 (UniProtKB)
Alt. Names/Synonyms: 2610319K07Rik; AI315591; AV001360; OTTMUSP00000004891; phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2; Pip4p2; PP4P2; PtdIns-4,5-P2 4-Ptase II; TM55A; Tmem55; Tmem55a; Transmembrane protein 55A; Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase; Type 2 PtdIns-4,5-P2 4-Ptase; Type II phosphatidylinositol 4,5-bisphosphate 4-phosphatase
Gene Symbols: Tmem55a
Molecular weight: 28,038 Da
Basal Isoelectric point: 9.07  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein