latrophilin 3 Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 4q13.1
Cellular Component:  axon; cell-cell junction; glutamatergic synapse; integral component of membrane; integral component of plasma membrane
Molecular Function:  calcium ion binding; carbohydrate binding; G protein-coupled receptor activity; protein binding
Biological Process:  cell surface receptor signaling pathway; cell-cell adhesion via plasma-membrane adhesion molecules; G protein-coupled receptor signaling pathway; locomotion involved in locomotory behavior; neuron migration; positive regulation of synapse assembly; response to cocaine; synapse assembly
Reference #:  Q9HAR2 (UniProtKB)
Alt. Names/Synonyms: ADGRL3; Adhesion G protein-coupled receptor L3; AGRL3; Calcium-independent alpha-latrotoxin receptor 3; CIRL-3; CIRL3; CL3; KIAA0768; latrophilin 3; latrophilin homolog 3 (cow); Latrophilin-3; LEC3; lectomedin 3; Lectomedin-3; LPHN3
Gene Symbols: ADGRL3
Molecular weight: 161,812 Da
Basal Isoelectric point: 5.99  Predict pI for various phosphorylation states
Select Structure to View Below

latrophilin 3

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB