latrophilin 3 Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of mouse Ortholog: 5|5 D-E1
Cellular Component:  anchoring junction; axon; cell projection; cell-cell junction; glutamatergic synapse; membrane; plasma membrane; postsynaptic membrane; Schaffer collateral - CA1 synapse
Molecular Function:  calcium ion binding; carbohydrate binding; G protein-coupled receptor activity; metal ion binding; protein binding; transmembrane signaling receptor activity
Biological Process:  adenylate cyclase-activating G protein-coupled receptor signaling pathway; cell surface receptor signaling pathway; cell-cell adhesion via plasma-membrane adhesion molecules; G protein-coupled receptor signaling pathway; locomotion involved in locomotory behavior; maintenance of postsynaptic specialization structure; neuron migration; positive regulation of synapse assembly; response to cocaine; signal transduction; synapse assembly; synapse organization
Reference #:  Q80TS3 (UniProtKB)
Alt. Names/Synonyms: 5430402I23Rik; Adgrl3; Adhesion G protein-coupled receptor L3; AGRL3; calcium-independent alpha-latrotoxin receptor homolog 3; CIRL-3; D130075K09Rik; G protein coupled receptor Lec3; Gm1379; Kiaa0768; latrophilin 3; Latrophilin-3; LEC; Lec3; lectomedin 3; Lectomedin-3; Lphn3; MGC99439; mKIAA0768
Gene Symbols: Adgrl3
Molecular weight: 171,080 Da
Basal Isoelectric point: 6.25  Predict pI for various phosphorylation states
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latrophilin 3

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene