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latrophilin 3
Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR |
| Chromosomal Location of mouse Ortholog: 5|5 D-E1 |
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Cellular Component:
anchoring junction; axon; cell projection; cell-cell junction; glutamatergic synapse; membrane; plasma membrane; postsynaptic membrane; Schaffer collateral - CA1 synapse
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Molecular Function:
calcium ion binding; carbohydrate binding; G protein-coupled receptor activity; metal ion binding; protein binding; transmembrane signaling receptor activity
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Biological Process:
adenylate cyclase-activating G protein-coupled receptor signaling pathway; cell surface receptor signaling pathway; cell-cell adhesion via plasma-membrane adhesion molecules; G protein-coupled receptor signaling pathway; locomotion involved in locomotory behavior; maintenance of postsynaptic specialization structure; neuron migration; positive regulation of synapse assembly; response to cocaine; signal transduction; synapse assembly; synapse organization
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Reference #:
Q80TS3
(UniProtKB)
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Alt. Names/Synonyms: 5430402I23Rik; Adgrl3; Adhesion G protein-coupled receptor L3; AGRL3; calcium-independent alpha-latrotoxin receptor homolog 3; CIRL-3; D130075K09Rik; G protein coupled receptor Lec3; Gm1379; Kiaa0768; latrophilin 3; Latrophilin-3; LEC; Lec3; lectomedin 3; Lectomedin-3; Lphn3; MGC99439; mKIAA0768
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Gene Symbols: Adgrl3
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Molecular weight:
171,080 Da
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Basal Isoelectric point:
6.25
Predict pI for various phosphorylation states
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