IFITM3 IFN-induced antiviral protein which disrupts intracellular cholesterol homeostasis. Inhibits the entry of viruses to the host cell cytoplasm by preventing viral fusion with cholesterol depleted endosomes. May inactivate new enveloped viruses which buds out of the infected cell, by letting them go out with a cholesterol depleted membrane. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV) and Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein-mediated viral entry. Plays a critical role in the structural stability and function of vacuolar ATPase (v-ATPase). Establishes physical contact with the v-ATPase of endosomes which is critical for proper clathrin localization and is also required for the function of the v-ATPase to lower the pH in phagocytic endosomes thus establishing an antiviral state. Belongs to the CD225/Dispanin family. Note: This description may include information from UniProtKB.
Protein type: Cell surface; Membrane protein, integral
Chromosomal Location of Human Ortholog: 7|7 F5
Cellular Component:  apical part of cell; cell surface; cytoplasm; cytoplasmic vesicle; endoplasmic reticulum; endosome; integral component of membrane; lysosome; membrane; nucleus; plasma membrane; protein-containing complex
Biological Process:  defense response to virus; immune system process; innate immune response; negative regulation of cell proliferation; negative regulation of viral entry into host cell; negative regulation of viral genome replication; negative regulation of viral transcription; receptor-mediated endocytosis; response to interferon-alpha; response to interferon-beta; response to interferon-gamma; response to virus; type I interferon signaling pathway
Reference #:  Q9CQW9 (UniProtKB)
Alt. Names/Synonyms: 1110004C05Rik; Cd225; Cdw217; Dispanin subfamily A member 2b; DSPA2b; Fgls; Fragilis; Fragilis protein; ifitm-like protein 1; Ifitm3; IFM3; Interferon induced transmembrane protein 3; Interferon-induced transmembrane protein 3; Interferon-inducible protein 15; IP15; MCG22590; mil; mil-1; Mouse ifitm-like protein 1
Gene Symbols: Ifitm3
Molecular weight: 14,954 Da
Basal Isoelectric point: 6.89  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene