LNK Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase. Belongs to the SH2B adapter family. Preferentially expressed by lymphoid cell lines. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 5 F|5 61.99 cM
Cellular Component:  plasma membrane
Molecular Function:  protein binding; protein tyrosine kinase binding; SH3/SH2 adaptor activity; signaling adaptor activity; stem cell factor receptor binding; transmembrane receptor protein tyrosine kinase adaptor activity
Biological Process:  cell differentiation; cellular response to chemokine; cellular response to interleukin-3; embryonic hemopoiesis; erythrocyte development; hemopoiesis; intracellular signal transduction; megakaryocyte development; monocyte homeostasis; negative regulation of cell proliferation; negative regulation of chemokine-mediated signaling pathway; negative regulation of JAK-STAT cascade; negative regulation of Kit signaling pathway; negative regulation of MAP kinase activity; negative regulation of platelet aggregation; negative regulation of protein kinase B signaling; negative regulation of response to cytokine stimulus; negative regulation of tyrosine phosphorylation of STAT protein; neutrophil homeostasis; signal transduction; thrombopoietin-mediated signaling pathway
Reference #:  O09039 (UniProtKB)
Alt. Names/Synonyms: AI429800; linker of T-cell receptor pathways; Lnk; Lymphocyte adapter protein; Lymphocyte-specific adapter protein Lnk; SH2B adapter protein 3; SH2B adaptor protein 3; Sh2b3; Signal transduction protein Lnk
Gene Symbols: Sh2b3
Molecular weight: 60,487 Da
Basal Isoelectric point: 6.73  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene