RGP1 The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors. Belongs to the RGP1 family. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 4|4 A5
Cellular Component:  cytoplasm; cytosol; Golgi membrane; membrane; plasma membrane; protein-containing complex; RIC1-RGP1 guanyl-nucleotide exchange factor complex
Molecular Function:  guanyl-nucleotide exchange factor activity; Rab GTPase binding; Rab guanyl-nucleotide exchange factor activity
Biological Process:  negative regulation of cellular protein catabolic process; positive regulation of GTPase activity; retrograde transport, endosome to Golgi
Reference #:  Q8BHT7 (UniProtKB)
Alt. Names/Synonyms: 1110029E03Rik; AI527196; F730001J03; Kiaa0258; mKIAA0258; OTTMUSP00000007438; RAB6A GEF compex partner 1; RAB6A-GEF complex partner protein 2; Retrograde Golgi transport protein RGP1 homolog; Rgp1; RGP1 retrograde golgi transport homolog; RGP1 retrograde golgi transport homolog (S. cerevisiae)
Gene Symbols: Rgp1
Molecular weight: 42,498 Da
Basal Isoelectric point: 5.61  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene