NRP2 High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF. (Microbial infection) Acts as a receptor for human cytomegalovirus pentamer-dependent entry in epithelial and endothelial cells. Belongs to the neuropilin family. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.
Chromosomal Location of Human Ortholog: 2q33.3
Cellular Component:  axon; extracellular region; glutamatergic synapse; integral component of membrane; integral component of postsynaptic membrane; membrane; plasma membrane; semaphorin receptor complex
Molecular Function:  cytokine binding; growth factor binding; heparin binding; metal ion binding; protein binding; semaphorin receptor activity; signaling receptor activity; vascular endothelial growth factor-activated receptor activity
Biological Process:  angiogenesis; axon extension involved in axon guidance; axon guidance; cell adhesion; cellular response to leukemia inhibitory factor; dorsal root ganglion morphogenesis; facial nerve structural organization; facioacoustic ganglion development; gonadotrophin-releasing hormone neuronal migration to the hypothalamus; negative chemotaxis; nerve development; neural crest cell migration involved in autonomic nervous system development; outflow tract septum morphogenesis; positive regulation of endothelial cell migration; positive regulation of endothelial cell proliferation; regulation of postsynapse organization; semaphorin-plexin signaling pathway involved in neuron projection guidance; sensory neuron axon guidance; sympathetic ganglion development; sympathetic neuron projection extension; sympathetic neuron projection guidance; trigeminal ganglion development; vascular endothelial growth factor receptor signaling pathway; vascular endothelial growth factor signaling pathway; ventral trunk neural crest cell migration; vestibulocochlear nerve structural organization; viral process
Reference #:  O60462 (UniProtKB)
Alt. Names/Synonyms: MGC126574; neuropilin 2; Neuropilin-2; neuropilin-2a(17); neuropilin-2a(22); neuropilin-2b(0); NP2; NPN2; NRP2; PRO2714; receptor for VEGF165 and semaphorins class3; Vascular endothelial cell growth factor 165 receptor 2; vascular endothelial growth factor-165 receptor 2; VEGF165R2
Gene Symbols: NRP2
Molecular weight: 104,859 Da
Basal Isoelectric point: 5.04  Predict pI for various phosphorylation states
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NRP2

Protein Structure Not Found.


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