RAB11A The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The small Rab GTPase RAB11A regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes. May also play a role in melanosome transport and release from melanocytes. Belongs to the small GTPase superfamily. Rab family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Protein type: G protein; G protein, monomeric; G protein, monomeric, Rab; Motility/polarity/chemotaxis

Chromosomal Location of human Ortholog: 15q22.31

Cellular Component: centriolar satellite; centriole; centrosome; cleavage furrow; cytoplasmic vesicle; cytoplasmic vesicle membrane; cytosol; extracellular exosome; glutamatergic synapse; Golgi apparatus; intracellular membrane-bounded organelle; kinetochore microtubule; multivesicular body; phagocytic vesicle; postsynaptic recycling endosome; protein-containing complex; recycling endosome; recycling endosome membrane; spindle pole; trans-Golgi network; transport vesicle; vesicle

Molecular Function: G protein activity; GTP binding; GTPase activity; microtubule binding; myosin V binding; protein binding; syntaxin binding

Biological Process: amyloid-beta clearance by transcytosis; astral microtubule organization; establishment of protein localization to membrane; establishment of protein localization to organelle; establishment of vesicle localization; exocytosis; exosomal secretion; melanosome transport; mitotic metaphase plate congression; mitotic spindle assembly; multivesicular body assembly; neuron projection development; neurotransmitter receptor transport, endosome to postsynaptic membrane; plasma membrane to endosome transport; positive regulation of epithelial cell migration; positive regulation of G2/M transition of mitotic cell cycle; protein localization to cell surface; protein localization to plasma membrane; regulation of cytokinesis; regulation of multivesicular body size; regulation of vesicle-mediated transport; vesicle-mediated transport

Reference #: P62491 (UniProtKB)

Alt. Names/Synonyms: MGC1490; RAB 11A, member oncogene family; Rab-11; RAB11; RAB11A; RAB11A, member RAS oncogene family; Ras-related protein Rab-11A; RB11A; YL8

Gene Symbols: RAB11A

Molecular weight: 24,394 Da

Basal Isoelectric point: 6.12 Predict pI for various phosphorylation states

Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology^®

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RAB11A

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