GPR65 Receptor for the glycosphingolipid psychosine (PSY) and several related glycosphingolipids. Plays a role in immune response by maintaining lysosome function and supporting phagocytosis-mediated intracellular bacteria clearance. May have a role in activation-induced cell death or differentiation of T-cells. Belongs to the G-protein coupled receptor 1 family. Predominantly expressed in thymus, spleen, lymph nodes, small intestine, lung, placenta and peripheral blood leukocytes. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 14q31.3
Cellular Component:  plasma membrane
Molecular Function:  G protein-coupled receptor activity
Biological Process:  actin cytoskeleton reorganization; activation of GTPase activity; adenylate cyclase-activating G protein-coupled receptor signaling pathway; apoptotic process; G protein-coupled receptor signaling pathway; immune response; multicellular organism development; positive regulation of stress fiber assembly; response to acidic pH
Reference #:  Q8IYL9 (UniProtKB)
Alt. Names/Synonyms: G protein-coupled receptor 65; G-protein coupled receptor 65; GPR65; hTDAG8; Psychosine receptor; PSYR; T-cell death-associated gene 8 protein; TDAG8
Gene Symbols: GPR65
Molecular weight: 39,333 Da
Basal Isoelectric point: 8.12  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB