TSG101 Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. Required for the exosomal release of SDCBP, CD63 and syndecan. It may also play a role in the extracellular release of microvesicles that differ from the exosomes. Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily. Heart, brain, placenta, lung, liver, skeletal, kidney and pancreas. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 11p15.1
Cellular Component:  cytoplasm; cytosol; early endosome; early endosome membrane; endosome; endosome membrane; ESCRT I complex; extracellular exosome; Flemming body; host cell; late endosome; late endosome membrane; microtubule organizing center; multivesicular body; nucleolus; plasma membrane
Molecular Function:  calcium-dependent protein binding; DNA binding; nuclear receptor transcription coactivator activity; protein binding; protein homodimerization activity; protein-containing complex binding; transcription corepressor activity; ubiquitin binding; ubiquitin protein ligase binding; virion binding
Biological Process:  autophagosome maturation; cell cycle arrest; cell division; endosomal transport; endosome to lysosome transport; exosomal secretion; extracellular transport; intracellular transport of virus; keratinocyte differentiation; macroautophagy; multivesicular body assembly; negative regulation of cell proliferation; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of epidermal growth factor-activated receptor activity; negative regulation of transcription, DNA-templated; positive regulation of exosomal secretion; positive regulation of nucleic acid-templated transcription; positive regulation of ubiquitin-dependent endocytosis; positive regulation of viral budding via host ESCRT complex; positive regulation of viral release from host cell; protein monoubiquitination; protein transport; regulation of cell growth; regulation of extracellular exosome assembly; regulation of MAP kinase activity; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; viral budding; viral budding via host ESCRT complex; viral life cycle
Disease: Breast Cancer
Reference #:  Q99816 (UniProtKB)
Alt. Names/Synonyms: ESCRT-I complex subunit TSG101; TS101; TSG10; TSG101; tumor susceptibility 101; tumor susceptibility gene 10; tumor susceptibility gene 101; Tumor susceptibility gene 101 protein; tumor susceptibility protein; VPS23
Gene Symbols: TSG101
Molecular weight: 43,944 Da
Basal Isoelectric point: 6.06  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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