DENND2B Isoform 1: May be involved in cytoskeletal organization and tumorogenicity. Seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Plays a role in EGFR trafficking from recycling endosomes back to the cell membrane. Isoform 2: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Isoform 3: May block ERK2 activation stimulated by ABL1. May alter cell morphology and cell growth. Widely expressed with the exception of peripheral blood lymphocytes. Isoform 1 is expressed in several epithelial and fibroblast (including tumorigenic) but absent in lymphoid cell lines (at protein level). Isoform 3 is expressed in primary cell or weakly tumorigenic but not in tumorigenic cell lines (at protein level). 3 human isoforms generated by alternative promoter usage or alternative splicing have been reported. Note: This description may include information from UniProtKB.
Protein type: GEF; GEF, Rab
Chromosomal Location of Human Ortholog: 7 E3|7 57.27 cM
Cellular Component:  cytoplasm; endosome; membrane; plasma membrane
Molecular Function:  guanyl-nucleotide exchange factor activity; Rab guanyl-nucleotide exchange factor activity
Biological Process:  positive regulation of ERK1 and ERK2 cascade
Reference #:  Q924W7 (UniProtKB)
Alt. Names/Synonyms: 2010004M01Rik; 2610305K15Rik; DEN2B; DENN domain containing 2B; DENN domain-containing protein 2B; Denn2b; Dennd2b; HeLa tumor suppression 1; St5; suppression of tumorigenicity 5; Suppression of tumorigenicity 5 protein
Gene Symbols: St5
Molecular weight: 126,861 Da
Basal Isoelectric point: 9.25  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene