SLC6A8 Required for the uptake of creatine in muscles and brain. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A8 subfamily. Predominantly expressed in skeletal muscle and kidney. Also found in brain, heart, colon, testis and prostate. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Transporter; Transporter, SLC family
Chromosomal Location of human Ortholog: Xq28
Cellular Component:  glutamatergic synapse; integral component of membrane; integral component of postsynaptic membrane; plasma membrane
Molecular Function:  creatine transmembrane transporter activity; neurotransmitter:sodium symporter activity
Biological Process:  choline transport; creatine metabolic process; creatine transmembrane transport; embryonic brain development; muscle contraction; sodium ion transport
Disease: Cerebral Creatine Deficiency Syndrome 1
Reference #:  P48029 (UniProtKB)
Alt. Names/Synonyms: CCDS1; Creatine transporter 1; creatine transporter SLC6A8; creatine transporter SLC6A8 variant D; CRT; CRTR; CT1; CTR5; MGC87396; SC6A8; SLC6A8; Sodium- and chloride-dependent creatine transporter 1; solute carrier family 6 (neurotransmitter transporter), member 8; solute carrier family 6 (neurotransmitter transporter, creatine), member 8; Solute carrier family 6 member 8
Gene Symbols: SLC6A8
Molecular weight: 70,523 Da
Basal Isoelectric point: 6.02  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein