PLXNA1 Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down- stream signaling events in the cytoplasm. Interacts directly with NRP1 and NRP2. Interacts with FARP2, RND1 and KDR/VEGFR2. Binding of SEMA3A leads to dissociation of FARP2. Detected in fetal brain, lung, liver and kidney. Belongs to the plexin family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.
Chromosomal Location of Human Ortholog: 6|6 D1
Cellular Component:  integral component of membrane; integral component of plasma membrane; membrane; plasma membrane; semaphorin receptor complex
Molecular Function:  protein binding; semaphorin receptor activity
Biological Process:  dichotomous subdivision of terminal units involved in salivary gland branching; negative regulation of cell adhesion; neuron projection extension; neuron projection guidance; positive regulation of axonogenesis; regulation of cell migration; regulation of cell shape; regulation of GTPase activity; regulation of smooth muscle cell migration; semaphorin-plexin signaling pathway; semaphorin-plexin signaling pathway involved in axon guidance; signal transduction
Reference #:  P70206 (UniProtKB)
Alt. Names/Synonyms: 2600013D04Rik; Kiaa4053; mKIAA4053; NOV; Plex 1; plexin 1; plexin A1; Plexin-1; Plexin-A1; PLXA1; Plxn1; Plxna1
Gene Symbols: Plxna1
Molecular weight: 211,099 Da
Basal Isoelectric point: 6.48  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene