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PLXNA1
Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. Belongs to the plexin family. Detected in fetal brain, lung, liver and kidney. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. |
| Chromosomal Location of mouse Ortholog: 6|6 D1 |
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Cellular Component:
cytosol; membrane; nucleoplasm; plasma membrane; semaphorin receptor complex
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Molecular Function:
protein binding; semaphorin receptor activity
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Biological Process:
dichotomous subdivision of terminal units involved in salivary gland branching; gonadotrophin-releasing hormone neuronal migration to the hypothalamus; negative regulation of cell adhesion; neuron projection extension; neuron projection guidance; olfactory nerve formation; positive regulation of axonogenesis; regulation of cell migration; regulation of cell shape; regulation of GTPase activity; regulation of smooth muscle cell migration; semaphorin-plexin signaling pathway; semaphorin-plexin signaling pathway involved in axon guidance
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Reference #:
P70206
(UniProtKB)
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Alt. Names/Synonyms: 2600013D04Rik; Kiaa4053; mKIAA4053; NOV; Ple; Plex 1; PlexA1; plexin 1; plexin A1; Plexin-1; Plexin-A1; PLXA1; Plxn1; Plxna1
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Gene Symbols: Plxna1
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Molecular weight:
211,099 Da
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Basal Isoelectric point:
6.48
Predict pI for various phosphorylation states
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CST Pathways:
Actin Dynamics
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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