TNFRSF11B Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis. Highly expressed in adult lung, heart, kidney, liver, spleen, thymus, prostate, ovary, small intestine, thyroid, lymph node, trachea, adrenal gland, testis, and bone marrow. Detected at very low levels in brain, placenta and skeletal muscle. Highly expressed in fetal kidney, liver and lung. Note: This description may include information from UniProtKB.
Protein type: Inhibitor; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 8q24.12
Cellular Component:  extracellular matrix; extracellular region; extracellular space; plasma membrane
Molecular Function:  cytokine activity; protein binding; signaling receptor activity
Biological Process:  apoptotic process; extracellular matrix organization; negative regulation of bone resorption; negative regulation of odontogenesis of dentin-containing tooth; regulation of signaling receptor activity; response to arsenic-containing substance; response to drug; response to estrogen; response to magnesium ion; response to nutrient; signal transduction; skeletal system development; tumor necrosis factor-mediated signaling pathway
Disease: Paget Disease, Juvenile
Reference #:  O00300 (UniProtKB)
Alt. Names/Synonyms: MGC29565; OCIF; OPG; Osteoclastogenesis inhibitory factor; Osteoprotegerin; TNFRSF11B; TR1; TR11B; Tumor necrosis factor receptor superfamily member 11B; tumor necrosis factor receptor superfamily, member 11b
Gene Symbols: TNFRSF11B
Molecular weight: 46,026 Da
Basal Isoelectric point: 8.66  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene