MYO10 Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as plus end-directed motor. The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments. Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and elongation of filopodia. May play a role in neurite outgrowth and axon guidance. In hippocampal neurons it induces the formation of dendritic filopodia by trafficking the actin-remodeling protein VASP to the tips of filopodia, where it promotes actin elongation. Plays a role in formation of the podosome belt in osteoclasts. Isoform Headless: Functions as a dominant-negative regulator of isoform 1, suppressing its filopodia-inducing and axon outgrowth-promoting activities. In hippocampal neurons, it increases VASP retention in spine heads to induce spine formation and spine head expansion. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. Ubiquitous. 3 human isoforms generated by alternative promoter usage or alternative splicing have been reported. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Motor
Chromosomal Location of Human Ortholog: 15 B1|15 9.36 cM
Cellular Component:  cell projection; cytoplasm; cytoskeleton; cytosol; filopodium; lamellipodium; membrane; myosin complex; neuron projection; neuronal cell body; nucleolus; plasma membrane; ruffle
Molecular Function:  actin binding; actin filament binding; ATP binding; calmodulin binding; motor activity; nucleotide binding; protein binding; spectrin binding
Biological Process:  cell motility; positive regulation of cell-cell adhesion; regulation of cell shape; regulation of filopodium assembly
Reference #:  F8VQB6 (UniProtKB)
Alt. Names/Synonyms: AW048724; D15Ertd600e; mKIAA0799; myo 10; Myo10; Myosin X; myosin-X; OTTMUSP00000022066; Unconventional myosin-X
Gene Symbols: Myo10
Molecular weight: 237,323 Da
Basal Isoelectric point: 5.88  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene