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APBB2
May modulate the internalization of amyloid-beta precursor protein. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Apoptosis |
| Chromosomal Location of Human Ortholog: 4p14-p13 |
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Cellular Component:
growth cone; lamellipodium; membrane; nucleus; synapse
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Molecular Function:
amyloid-beta binding; protein binding; transcription factor binding
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Biological Process:
axon guidance; cell cycle arrest; extracellular matrix organization; intracellular signal transduction; negative regulation of apoptotic process; negative regulation of cell growth; neuron migration; positive regulation of apoptotic process; regulation of transcription, DNA-templated
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Disease: Alzheimer Disease
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Reference #:
Q92870
(UniProtKB)
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Alt. Names/Synonyms: amyloid beta (A4) precursor protein-binding, family B, member 2; Amyloid beta A4 precursor protein-binding family B member 2; amyloid beta precursor protein binding family B member 2; Amyloid-beta A4 precursor protein-binding family B member 2; APBB2; DKFZp434E033; Fe65-like 1; FE65L; FE65L1; MGC35575; Protein Fe65-like 1
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Gene Symbols: APBB2
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Molecular weight:
83,374 Da
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Basal Isoelectric point:
5.74
Predict pI for various phosphorylation states
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