APBB2 May modulate the internalization of amyloid-beta precursor protein. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Apoptosis
Chromosomal Location of Human Ortholog: 4p14-p13
Cellular Component:  growth cone; lamellipodium; membrane; nucleus; synapse
Molecular Function:  amyloid-beta binding; protein binding; transcription factor binding
Biological Process:  axon guidance; cell cycle arrest; extracellular matrix organization; intracellular signal transduction; negative regulation of apoptotic process; negative regulation of cell growth; neuron migration; positive regulation of apoptotic process; regulation of transcription, DNA-templated
Disease: Alzheimer Disease
Reference #:  Q92870 (UniProtKB)
Alt. Names/Synonyms: amyloid beta (A4) precursor protein-binding, family B, member 2; Amyloid beta A4 precursor protein-binding family B member 2; amyloid beta precursor protein binding family B member 2; Amyloid-beta A4 precursor protein-binding family B member 2; APBB2; DKFZp434E033; Fe65-like 1; FE65L; FE65L1; MGC35575; Protein Fe65-like 1
Gene Symbols: APBB2
Molecular weight: 83,374 Da
Basal Isoelectric point: 5.74  Predict pI for various phosphorylation states
Select Structure to View Below

APBB2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein