PR The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as transcriptional activator or repressor. Isoform A: Ligand-dependent transdominant repressor of steroid hormone receptor transcriptional activity including repression of its isoform B, MR and ER. Transrepressional activity may involve recruitment of corepressor NCOR2. Isoform B: Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation. Isoform 4: Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone. Belongs to the nuclear hormone receptor family. NR3 subfamily. In reproductive tissues the expression of isoform A and isoform B varies as a consequence of developmental and hormonal status. Isoform A and isoform B are expressed in comparable levels in uterine glandular epithelium during the proliferative phase of the menstrual cycle. Expression of isoform B but not of isoform A persists in the glands during mid-secretory phase. In the stroma, isoform A is the predominant form throughout the cycle. Heterogeneous isoform expression between the glands of the endometrium basalis and functionalis is implying region-specific responses to hormonal stimuli. 5 human isoforms generated by alternative promoter usage or alternative splicing have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nuclear receptor; Transcription factor
Chromosomal Location of Human Ortholog: 11q22.1
Cellular Component:  cytosol; mitochondrial outer membrane; nucleoplasm
Molecular Function:  ATPase binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; enzyme binding; identical protein binding; nuclear receptor activity; protein binding; RNA polymerase II proximal promoter sequence-specific DNA binding; steroid binding; steroid hormone receptor activity; zinc ion binding
Biological Process:  cell-cell signaling; epithelial cell maturation; lung alveolus development; negative regulation of gene expression; ovulation from ovarian follicle; paracrine signaling; positive regulation of transcription by RNA polymerase II; progesterone receptor signaling pathway; regulation of epithelial cell proliferation; signal transduction; tertiary branching involved in mammary gland duct morphogenesis; transcription initiation from RNA polymerase II promoter
Disease: Progesterone Resistance
Reference #:  P06401 (UniProtKB)
Alt. Names/Synonyms: NR3C3; Nuclear receptor subfamily 3 group C member 3; PGR; PR; PRGR; Progesterone receptor
Gene Symbols: PGR
Molecular weight: 98,981 Da
Basal Isoelectric point: 6.09  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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