|
PI4K2A
Membrane-bound phosphatidylinositol-4 kinase (PI4-kinase) that catalyzes the phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P), a lipid that plays important roles in endocytosis, Golgi function, protein sorting and membrane trafficking and is required for prolonged survival of neurons. Besides, phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P) is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily. Widely expressed. Highest expression is observed in kidney, brain, heart, skeletal muscle, and placenta and lowest expression is observed in colon, thymus, and small intestine. Note: This description may include information from UniProtKB.
|
| Protein type: EC 2.7.1.67; Kinase, lipid; Motility/polarity/chemotaxis |
| Chromosomal Location of mouse Ortholog: 19 C3|19 35.74 cM |
|
Cellular Component:
BLOC-1 complex; cell projection; cytoplasmic vesicle; dendrite; early endosome membrane; endosome; exocytic vesicle; Golgi apparatus; Golgi membrane; growing cell tip; membrane; membrane raft; mitochondrion; neuron projection; neuronal cell body; perikaryon; plasma membrane; presynaptic membrane; protein-containing complex; synapse; synaptic vesicle membrane; trans-Golgi network
|
|
Molecular Function:
1-phosphatidylinositol 4-kinase activity; AP-3 adaptor complex binding; ATP binding; kinase activity; nucleotide binding; protein-containing complex binding; transferase activity
|
|
Biological Process:
basophil degranulation; endosome organization; Golgi organization; lipid metabolic process; phosphatidylinositol biosynthetic process; phosphatidylinositol phosphate biosynthetic process; phosphorylation
|
|
Reference #:
Q2TBE6
(UniProtKB)
|
|
Alt. Names/Synonyms: MGC118011; MGC37783; P4K2A; phosphatidylinositol 4-kinase type 2 alpha; Phosphatidylinositol 4-kinase type 2-alpha; Phosphatidylinositol 4-kinase type II-alpha; phosphatidylinositol 4-kinase type II-like; Pi4k2; Pi4k2a; PI4KII
|
|
Gene Symbols: Pi4k2a
|
|
Molecular weight:
54,258 Da
|
|
Basal Isoelectric point:
8.25
Predict pI for various phosphorylation states
|
