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tensin 3
May play a role in actin remodeling. Involved in the dissociation of the integrin-tensin-actin complex. EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1. Seems to be involved in mammary cell migration. May be involved in cell migration and bone development. Expressed in umbilical vein endothelial cells, epithelial cells, and fibroblasts cells (at protein level). Highly expressed in thyroid, kidney and placenta. Low expression in heart, skeletal muscle, spleen, liver, and lung. Expressed in tumor endothelial cells. Expression seems to be down-regulated in thyroid tumor tissues and in anaplastic carcinomas. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis |
| Chromosomal Location of mouse Ortholog: 11|11 A1 |
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Cellular Component:
anchoring junction; cell projection; cytosol; focal adhesion; podosome
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Molecular Function:
guanyl-nucleotide exchange factor adaptor activity; hydrolase activity; phosphatase activity; phosphoprotein phosphatase activity; protein binding
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Biological Process:
bone resorption; cell population proliferation; dephosphorylation; endothelial cell migration; lung alveolus development; negative regulation of Rho protein signal transduction; podosome assembly; positive regulation of cell population proliferation; positive regulation of guanyl-nucleotide exchange factor activity; positive regulation of Rac protein signal transduction
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Reference #:
Q5SSZ5
(UniProtKB)
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Alt. Names/Synonyms: BC023928; F830010I22Rik; OTTMUSP00000005346; TEM6; Ten; Tens1; TENS3; tensin 3; Tensin-3; tensin-like SH2 domain containing 1; Tensin-like SH2 domain-containing protein 1; Tns3; tumor endothelial marker 6
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Gene Symbols: Tns3
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Molecular weight:
155,589 Da
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Basal Isoelectric point:
6.19
Predict pI for various phosphorylation states
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CST Pathways:
ErbB/HER Signaling
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