PPP1R11 Atypical E3 ubiquitin-protein ligase which ubiquitinates TLR2 at 'Lys-754' leading to its degradation by the proteasome. Plays a role in regulating inflammatory cytokine release and gram-positive bacterial clearance by functioning, in part, through the ubiquitination and degradation of TLR2. Inhibitor of protein phosphatase 1. Widely expressed. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of mouse Ortholog: 17 B1|17 19.16 cM
Cellular Component:  cytoplasm; nucleus
Molecular Function:  molecular function inhibitor activity; protein binding; protein phosphatase 1 binding; protein phosphatase inhibitor activity; protein serine/threonine phosphatase inhibitor activity; transferase activity; ubiquitin protein ligase activity
Biological Process:  defense response to Gram-positive bacterium; negative regulation of cytokine production; ubiquitin-dependent protein catabolic process
Reference #:  Q8K1L5 (UniProtKB)
Alt. Names/Synonyms: 1500041B02Rik; AV117883; E3 ubiquitin-protein ligase PPP1R11; HCG; HCG-; HCGV; PP1RB; Ppp1r11; Protein phosphatase 1 regulatory subunit 11; protein phosphatase 1, regulatory (inhibitor) subunit 11; protein phosphatase 1, regulatory inhibitor subunit 11; T-complex testis expressed protein 5; t-complex testis-expressed 5; Tcte5; Tctex-5; Tctex5
Gene Symbols: Ppp1r11
Molecular weight: 14,544 Da
Basal Isoelectric point: 5.75  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein