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PPP1R11
Atypical E3 ubiquitin-protein ligase which ubiquitinates TLR2 at 'Lys-754' leading to its degradation by the proteasome. Plays a role in regulating inflammatory cytokine release and gram-positive bacterial clearance by functioning, in part, through the ubiquitination and degradation of TLR2. Inhibitor of protein phosphatase 1. Widely expressed. Note: This description may include information from UniProtKB.
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| Protein type: Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit; Ubiquitin conjugating system; Ubiquitin ligase |
| Chromosomal Location of mouse Ortholog: 17 B1|17 19.16 cM |
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Cellular Component:
cytoplasm; nucleus
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Molecular Function:
molecular function inhibitor activity; protein binding; protein phosphatase 1 binding; protein phosphatase inhibitor activity; protein serine/threonine phosphatase inhibitor activity; transferase activity; ubiquitin protein ligase activity
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Biological Process:
defense response to Gram-positive bacterium; negative regulation of cytokine production; ubiquitin-dependent protein catabolic process
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Reference #:
Q8K1L5
(UniProtKB)
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Alt. Names/Synonyms: 1500041B02Rik; AV117883; E3 ubiquitin-protein ligase PPP1R11; HCG; HCG-; HCGV; PP1RB; Ppp1r11; Protein phosphatase 1 regulatory subunit 11; protein phosphatase 1, regulatory (inhibitor) subunit 11; protein phosphatase 1, regulatory inhibitor subunit 11; T-complex testis expressed protein 5; t-complex testis-expressed 5; Tcte5; Tctex-5; Tctex5
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Gene Symbols: Ppp1r11
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Molecular weight:
14,544 Da
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Basal Isoelectric point:
5.75
Predict pI for various phosphorylation states
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