KDELC2 Protein glucosyltransferase that catalyzes the transfer of glucose from UDP-glucose to a serine residue within the consensus sequence peptide C-X-N-T-X-G-S-F-X-C. Can also catalyze the transfer of xylose from UDP-xylose but less efficiently. Specifically targets extracellular EGF repeats of proteins such as NOTCH1 and NOTCH3. May regulate the transport of NOTCH1 and NOTCH3 to the plasma membrane and thereby the Notch signaling pathway. Belongs to the KDELC family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.4.1.-; EC 2.4.2.26; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 9|9 A5.3
Cellular Component:  endoplasmic reticulum; endoplasmic reticulum lumen
Molecular Function:  glucosyltransferase activity; protein xylosyltransferase activity; transferase activity; transferase activity, transferring glycosyl groups; UDP-glucosyltransferase activity; UDP-xylosyltransferase activity
Biological Process:  protein O-linked glycosylation via serine
Reference #:  G5E897 (UniProtKB)
Alt. Names/Synonyms: 2010004J24Rik; 4833410J10Rik; AW549401; KDEL (Lys-Asp-Glu-Leu) containing 2; KDEL (Lys-Asp-Glu-Leu) containing 2 protein; KDEL motif-containing protein 2; Kdelc; Kdelc2; PLGT3; Poglut3; Protein O-glucosyltransferase 3; Protein O-xylosyltransferase POGLUT3
Gene Symbols: Poglut3
Molecular weight: 57,686 Da
Basal Isoelectric point: 7.62  Predict pI for various phosphorylation states
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KDELC2

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein